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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2R5A
All Species:
39.09
Human Site:
Y400
Identified Species:
66.15
UniProt:
Q15172
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15172
NP_006234.1
486
56194
Y400
P
I
M
F
A
S
L
Y
K
I
S
K
E
H
W
Chimpanzee
Pan troglodytes
XP_001151388
673
75031
L607
F
W
N
N
E
Y
I
L
S
L
I
E
E
N
I
Rhesus Macaque
Macaca mulatta
XP_001106979
628
70785
Y542
P
I
M
F
A
S
L
Y
K
I
S
K
E
H
W
Dog
Lupus familis
XP_547400
566
64736
Y480
P
I
M
F
G
S
L
Y
K
I
S
K
E
H
W
Cat
Felis silvestris
Mouse
Mus musculus
Q6PD03
486
56328
Y400
P
I
M
F
A
S
L
Y
K
I
S
K
E
H
W
Rat
Rattus norvegicus
NP_001101361
486
56318
Y400
P
I
M
F
A
S
L
Y
K
I
S
K
E
H
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509703
483
55774
Y396
P
I
M
F
G
S
L
Y
K
I
S
K
E
H
W
Chicken
Gallus gallus
XP_419432
476
55266
Y390
P
I
M
F
G
S
L
Y
K
I
S
K
E
H
W
Frog
Xenopus laevis
NP_001086500
476
55192
Y389
P
I
M
F
G
S
L
Y
K
I
S
K
E
H
W
Zebra Danio
Brachydanio rerio
XP_690932
478
56125
Y392
P
I
M
F
G
N
L
Y
R
I
S
K
E
H
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651569
524
59708
Y387
P
I
M
F
P
A
L
Y
R
I
S
K
E
H
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780697
432
50137
E367
A
L
Y
F
W
N
N
E
Y
V
V
S
L
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LU89
510
58740
E443
P
I
I
F
P
A
L
E
R
N
A
Q
K
H
W
Baker's Yeast
Sacchar. cerevisiae
P38903
757
85316
Q650
D
P
Y
M
L
V
E
Q
A
I
N
S
G
S
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.6
74.3
85.1
N.A.
97.7
97.9
N.A.
95
93.2
88
80
N.A.
66.7
N.A.
N.A.
68.3
Protein Similarity:
100
66.1
74.5
85.1
N.A.
98.7
98.7
N.A.
97.5
95.8
94
88.8
N.A.
78
N.A.
N.A.
78.8
P-Site Identity:
100
6.6
100
93.3
N.A.
100
100
N.A.
93.3
93.3
93.3
80
N.A.
80
N.A.
N.A.
6.6
P-Site Similarity:
100
33.3
100
93.3
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
93.3
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.2
37.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
65.2
49.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
29
15
0
0
8
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
8
15
0
0
0
8
79
0
8
% E
% Phe:
8
0
0
86
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
36
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
79
0
% H
% Ile:
0
79
8
0
0
0
8
0
0
79
8
0
0
8
8
% I
% Lys:
0
0
0
0
0
0
0
0
58
0
0
72
8
0
0
% K
% Leu:
0
8
0
0
8
0
79
8
0
8
0
0
8
0
0
% L
% Met:
0
0
72
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
15
8
0
0
8
8
0
0
8
0
% N
% Pro:
79
8
0
0
15
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
22
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
58
0
0
8
0
72
15
0
8
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
8
8
0
0
0
0
% V
% Trp:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
86
% W
% Tyr:
0
0
15
0
0
8
0
72
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _