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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPA1 All Species: 52.42
Human Site: T186 Identified Species: 76.89
UniProt: Q15181 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15181 NP_066952.1 289 32660 T186 K P G Y L E A T V D W F R R Y
Chimpanzee Pan troglodytes XP_001164495 327 36742 T224 K P G Y L E A T V D W F R R Y
Rhesus Macaque Macaca mulatta XP_001107614 488 53839 T385 K P G Y L E A T V D W F R R Y
Dog Lupus familis XP_536380 290 32918 T187 K P G Y L E A T V D W F R R Y
Cat Felis silvestris
Mouse Mus musculus Q9D819 289 32649 T186 K P G Y L E A T V D W F R R Y
Rat Rattus norvegicus NP_001094304 289 32753 T186 K P G Y L E A T V D W F R R Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232700 290 32618 T188 K P G Y L E A T V D W F R R Y
Frog Xenopus laevis NP_001086030 289 32999 T187 K P N Y L E S T V D W F R R Y
Zebra Danio Brachydanio rerio NP_001017833 291 32624 T187 K P G Y L E A T V D W F R R Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77460 338 37921 T236 F P G L L R A T V E W F K I Y
Honey Bee Apis mellifera XP_393267 745 83891 T230 Y P G L M K A T I E W F K I Y
Nematode Worm Caenorhab. elegans Q18680 407 44134 S309 Y P G L L A A S V E W F R N Y
Sea Urchin Strong. purpuratus XP_793193 270 30364 P180 Y K V P D G K P L N E F A F N
Poplar Tree Populus trichocarpa
Maize Zea mays O48556 214 24351 K136 P M I D Q G E K D D K I I A V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P00817 287 32281 T186 F P G L L R A T N E W F R I Y
Red Bread Mold Neurospora crassa Q6MVH7 290 32621 T188 L P G L I R A T N E W F R I Y
Conservation
Percent
Protein Identity: 100 88 59 93 N.A. 94.1 92.3 N.A. N.A. 77.5 72.3 72.8 N.A. 47.9 23 38.8 53.9
Protein Similarity: 100 88.3 59.2 95.8 N.A. 98.9 98.6 N.A. N.A. 90.6 84.7 85.5 N.A. 60.3 29.9 53.8 68.5
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 86.6 100 N.A. 60 46.6 60 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 93.3 100 N.A. 73.3 80 73.3 20
Percent
Protein Identity: N.A. 21.1 N.A. N.A. 52.6 49.3
Protein Similarity: N.A. 38 N.A. N.A. 70.2 68.6
P-Site Identity: N.A. 6.6 N.A. N.A. 60 53.3
P-Site Similarity: N.A. 6.6 N.A. N.A. 66.6 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 82 0 0 0 0 0 7 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 7 0 0 0 7 63 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 57 7 0 0 32 7 0 0 0 0 % E
% Phe: 13 0 0 0 0 0 0 0 0 0 0 94 0 7 0 % F
% Gly: 0 0 82 0 0 13 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 7 0 0 0 7 0 0 7 7 25 0 % I
% Lys: 57 7 0 0 0 7 7 7 0 0 7 0 13 0 0 % K
% Leu: 7 0 0 32 75 0 0 0 7 0 0 0 0 0 0 % L
% Met: 0 7 0 0 7 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 13 7 0 0 0 7 7 % N
% Pro: 7 88 0 7 0 0 0 7 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 19 0 0 0 0 0 0 75 57 0 % R
% Ser: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 82 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 0 0 0 69 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 88 0 0 0 0 % W
% Tyr: 19 0 0 57 0 0 0 0 0 0 0 0 0 0 88 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _