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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPA1 All Species: 33.03
Human Site: T235 Identified Species: 48.44
UniProt: Q15181 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15181 NP_066952.1 289 32660 T235 K A L V T K K T N G K G I S C
Chimpanzee Pan troglodytes XP_001164495 327 36742 T273 K A L V T K K T N G K G I S C
Rhesus Macaque Macaca mulatta XP_001107614 488 53839 T434 K A L V T K K T N G K G I S C
Dog Lupus familis XP_536380 290 32918 I236 R A L V T K K I D G K G I S C
Cat Felis silvestris
Mouse Mus musculus Q9D819 289 32649 T235 K A L V T K K T D G K G I S C
Rat Rattus norvegicus NP_001094304 289 32753 T235 K A L V T K K T D G K G I S C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232700 290 32618 T237 K A L I A K K T D G G E I S C
Frog Xenopus laevis NP_001086030 289 32999 V236 K A L V A K K V E G G E I N C
Zebra Danio Brachydanio rerio NP_001017833 291 32624 T236 K A L L S Q Q T N A G E L N C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77460 338 37921 P285 Q N L V H Q S P A S G S I S T
Honey Bee Apis mellifera XP_393267 745 83891 A279 Q N L I K R E A P A G G I A C
Nematode Worm Caenorhab. elegans Q18680 407 44134 N358 K T L I K E A N P S L N T V S
Sea Urchin Strong. purpuratus XP_793193 270 30364 S215 Q K L I S G E S D A G K L S C
Poplar Tree Populus trichocarpa
Maize Zea mays O48556 214 24351 F171 L Q E I K R F F E D Y K K N E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P00817 287 32281 S235 K Q L I A G K S S D S K G I D
Red Bread Mold Neurospora crassa Q6MVH7 290 32621 T237 E R L I T G K T A P G G V S T
Conservation
Percent
Protein Identity: 100 88 59 93 N.A. 94.1 92.3 N.A. N.A. 77.5 72.3 72.8 N.A. 47.9 23 38.8 53.9
Protein Similarity: 100 88.3 59.2 95.8 N.A. 98.9 98.6 N.A. N.A. 90.6 84.7 85.5 N.A. 60.3 29.9 53.8 68.5
P-Site Identity: 100 100 100 80 N.A. 93.3 93.3 N.A. N.A. 66.6 60 40 N.A. 26.6 26.6 13.3 20
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 80 66.6 80 N.A. 40 60 26.6 66.6
Percent
Protein Identity: N.A. 21.1 N.A. N.A. 52.6 49.3
Protein Similarity: N.A. 38 N.A. N.A. 70.2 68.6
P-Site Identity: N.A. 0 N.A. N.A. 20 40
P-Site Similarity: N.A. 20 N.A. N.A. 40 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 57 0 0 19 0 7 7 13 19 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 69 % C
% Asp: 0 0 0 0 0 0 0 0 32 13 0 0 0 0 7 % D
% Glu: 7 0 7 0 0 7 13 0 13 0 0 19 0 0 7 % E
% Phe: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 19 0 0 0 50 44 50 7 0 0 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 44 0 0 0 7 0 0 0 0 63 7 0 % I
% Lys: 63 7 0 0 19 50 63 0 0 0 38 19 7 0 0 % K
% Leu: 7 0 94 7 0 0 0 0 0 0 7 0 13 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 13 0 0 0 0 0 7 25 0 0 7 0 19 0 % N
% Pro: 0 0 0 0 0 0 0 7 13 7 0 0 0 0 0 % P
% Gln: 19 13 0 0 0 13 7 0 0 0 0 0 0 0 0 % Q
% Arg: 7 7 0 0 0 13 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 13 0 7 13 7 13 7 7 0 63 7 % S
% Thr: 0 7 0 0 44 0 0 50 0 0 0 0 7 0 13 % T
% Val: 0 0 0 50 0 0 0 7 0 0 0 0 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _