Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPA1 All Species: 18.48
Human Site: T275 Identified Species: 27.11
UniProt: Q15181 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15181 NP_066952.1 289 32660 T275 P P C E S A C T V P T D V D K
Chimpanzee Pan troglodytes XP_001164495 327 36742 T313 P P C E S A C T V P T D V D K
Rhesus Macaque Macaca mulatta XP_001107614 488 53839 T474 P P C E S A C T V P T D V D K
Dog Lupus familis XP_536380 290 32918 T276 P P C E S A C T V P T D V D K
Cat Felis silvestris
Mouse Mus musculus Q9D819 289 32649 S275 P P C E S A C S L P T D V D K
Rat Rattus norvegicus NP_001094304 289 32753 A275 P P C E S A C A L P M D V D K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232700 290 32618 P276 P P C K A A N P I P P E V D R
Frog Xenopus laevis NP_001086030 289 32999 P275 P P C G P P S P V S E N V D K
Zebra Danio Brachydanio rerio NP_001017833 291 32624 P277 C A C G D A S P I P T S V D K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77460 338 37921 E324 P D G G Q V E E V S D T V D T
Honey Bee Apis mellifera XP_393267 745 83891 P447 I A C K G F C P C K A S D L R
Nematode Worm Caenorhab. elegans Q18680 407 44134 P394 P E H G A N A P L P G D V D K
Sea Urchin Strong. purpuratus XP_793193 270 30364 L252 K A A P V A D L I P R D P E V
Poplar Tree Populus trichocarpa
Maize Zea mays O48556 214 24351 Y204 I Q Y S M D L Y A Q Y I L Q S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P00817 287 32281 P272 A S P K A D A P I D K S I D K
Red Bread Mold Neurospora crassa Q6MVH7 290 32621 P274 N E N L P P A P I D S S I D K
Conservation
Percent
Protein Identity: 100 88 59 93 N.A. 94.1 92.3 N.A. N.A. 77.5 72.3 72.8 N.A. 47.9 23 38.8 53.9
Protein Similarity: 100 88.3 59.2 95.8 N.A. 98.9 98.6 N.A. N.A. 90.6 84.7 85.5 N.A. 60.3 29.9 53.8 68.5
P-Site Identity: 100 100 100 100 N.A. 86.6 80 N.A. N.A. 46.6 46.6 46.6 N.A. 26.6 13.3 40 20
P-Site Similarity: 100 100 100 100 N.A. 100 86.6 N.A. N.A. 80 53.3 53.3 N.A. 26.6 26.6 53.3 33.3
Percent
Protein Identity: N.A. 21.1 N.A. N.A. 52.6 49.3
Protein Similarity: N.A. 38 N.A. N.A. 70.2 68.6
P-Site Identity: N.A. 0 N.A. N.A. 13.3 13.3
P-Site Similarity: N.A. 6.6 N.A. N.A. 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 19 7 0 19 57 19 7 7 0 7 0 0 0 0 % A
% Cys: 7 0 63 0 0 0 44 0 7 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 7 13 7 0 0 13 7 50 7 82 0 % D
% Glu: 0 13 0 38 0 0 7 7 0 0 7 7 0 7 0 % E
% Phe: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 7 25 7 0 0 0 0 0 7 0 0 0 0 % G
% His: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 13 0 0 0 0 0 0 0 32 0 0 7 13 0 0 % I
% Lys: 7 0 0 19 0 0 0 0 0 7 7 0 0 0 69 % K
% Leu: 0 0 0 7 0 0 7 7 19 0 0 0 7 7 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 7 0 7 0 0 7 7 0 0 0 0 7 0 0 0 % N
% Pro: 63 50 7 7 13 13 0 44 0 63 7 0 7 0 0 % P
% Gln: 0 7 0 0 7 0 0 0 0 7 0 0 0 7 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 13 % R
% Ser: 0 7 0 7 38 0 13 7 0 13 7 25 0 0 7 % S
% Thr: 0 0 0 0 0 0 0 25 0 0 38 7 0 0 7 % T
% Val: 0 0 0 0 7 7 0 0 38 0 0 0 69 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 0 0 7 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _