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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2R4
All Species:
30.3
Human Site:
S241
Identified Species:
51.28
UniProt:
Q15257
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15257
NP_066954.2
358
40668
S241
Y
R
M
E
P
A
G
S
Q
G
V
W
G
L
D
Chimpanzee
Pan troglodytes
XP_001163459
373
41748
S256
Y
R
M
E
P
A
G
S
Q
G
V
W
G
L
D
Rhesus Macaque
Macaca mulatta
XP_001108890
359
40767
S241
Y
R
M
E
P
A
G
S
Q
G
V
W
G
L
D
Dog
Lupus familis
XP_548424
349
39477
S232
Y
R
M
E
P
A
G
S
Q
G
V
W
G
L
D
Cat
Felis silvestris
Mouse
Mus musculus
P58389
323
36692
F215
G
V
W
G
L
D
D
F
Q
F
L
P
F
I
W
Rat
Rattus norvegicus
NP_001102047
323
36599
F215
G
V
W
G
L
D
D
F
Q
F
L
P
F
I
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508723
358
40562
S242
Y
R
M
E
P
A
G
S
Q
G
V
W
G
L
D
Chicken
Gallus gallus
NP_001026542
321
36721
F214
G
V
W
G
L
D
D
F
Q
F
L
P
F
I
W
Frog
Xenopus laevis
NP_001089500
323
36857
D214
S
Q
G
V
W
G
L
D
D
F
Q
F
L
P
F
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523466
398
44238
F227
S
P
F
D
P
S
K
F
V
D
E
A
I
I
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784258
466
51558
S315
Y
N
M
E
P
A
G
S
Q
G
V
W
G
L
D
Poplar Tree
Populus trichocarpa
XP_002307365
396
45132
S275
Y
N
L
E
P
A
G
S
H
G
V
W
G
L
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40454
393
45064
V239
E
I
L
D
K
S
L
V
R
E
Y
K
D
T
N
Red Bread Mold
Neurospora crassa
Q7SEF9
449
50080
S262
Y
Y
L
E
P
A
G
S
H
G
V
W
G
L
D
Conservation
Percent
Protein Identity:
100
72.1
93.3
73.4
N.A.
86.8
85.7
N.A.
68.7
81.2
76.2
N.A.
N.A.
41.2
N.A.
N.A.
39
Protein Similarity:
100
76.9
96
77.3
N.A.
89.6
89.1
N.A.
75.9
85.1
82.6
N.A.
N.A.
56
N.A.
N.A.
50.4
P-Site Identity:
100
100
100
100
N.A.
6.6
6.6
N.A.
100
6.6
0
N.A.
N.A.
6.6
N.A.
N.A.
93.3
P-Site Similarity:
100
100
100
100
N.A.
20
20
N.A.
100
20
13.3
N.A.
N.A.
26.6
N.A.
N.A.
93.3
Percent
Protein Identity:
38.3
N.A.
N.A.
N.A.
36.1
30.2
Protein Similarity:
56.8
N.A.
N.A.
N.A.
50.3
43.8
P-Site Identity:
80
N.A.
N.A.
N.A.
0
80
P-Site Similarity:
86.6
N.A.
N.A.
N.A.
33.3
86.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
58
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
15
0
22
22
8
8
8
0
0
8
0
58
% D
% Glu:
8
0
0
58
0
0
0
0
0
8
8
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
29
0
29
0
8
22
0
8
% F
% Gly:
22
0
8
22
0
8
58
0
0
58
0
0
58
0
0
% G
% His:
0
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
8
29
0
% I
% Lys:
0
0
0
0
8
0
8
0
0
0
0
8
0
0
0
% K
% Leu:
0
0
22
0
22
0
15
0
0
0
22
0
8
58
0
% L
% Met:
0
0
43
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
8
0
0
65
0
0
0
0
0
0
22
0
8
0
% P
% Gln:
0
8
0
0
0
0
0
0
65
0
8
0
0
0
0
% Q
% Arg:
0
36
0
0
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
15
0
0
0
0
15
0
58
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% T
% Val:
0
22
0
8
0
0
0
8
8
0
58
0
0
0
0
% V
% Trp:
0
0
22
0
8
0
0
0
0
0
0
58
0
0
22
% W
% Tyr:
58
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _