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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: E2F5 All Species: 9.39
Human Site: T261 Identified Species: 14.76
UniProt: Q15329 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15329 NP_001077057.1 346 37610 T261 S Q S L T P V T P Q K S S M A
Chimpanzee Pan troglodytes XP_511025 426 45548 P246 S A V S T P P P L P K P A L A
Rhesus Macaque Macaca mulatta XP_001094919 346 37697 T261 S Q S L T P A T P Q K S S M A
Dog Lupus familis XP_853833 304 33793 K223 S T P V T A Q K S N I A T Q N
Cat Felis silvestris
Mouse Mus musculus Q61502 335 36766 T251 S Q S S T S V T P Q K S T M A
Rat Rattus norvegicus Q62814 300 33206 M222 V T P P K S T M A A Q N L P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517985 227 25092 Q148 P Q T P A T P Q T P N A A P S
Chicken Gallus gallus Q90977 403 43534 L320 A Q D V N M L L P E A L L P G
Frog Xenopus laevis NP_001086706 375 40890 Q223 P A V P S T P Q R P A L T P Q
Zebra Danio Brachydanio rerio NP_998597 393 42365 S223 S T P A S T T S A A A A P T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27368 805 87442 L579 I Q E L F S S L T E S S P P T
Honey Bee Apis mellifera XP_624285 300 34327 P222 K G I S K P D P V I S D E D E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_799123 356 39484 P271 S V I P V A E P M L T E T K I
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001130952 446 48668 A342 E N P R T P L A A D C N K V T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565831 483 52579 H378 S S S G S T G H H D I E A L T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 52.8 97.9 78.9 N.A. 88.1 82.6 N.A. 57.2 33 58.1 56.2 N.A. 20.6 41 N.A. 51.9
Protein Similarity: 100 62.2 98.5 82.6 N.A. 90.1 84.3 N.A. 60.6 49.6 68.8 66.1 N.A. 29.6 55.2 N.A. 65.1
P-Site Identity: 100 33.3 93.3 13.3 N.A. 80 0 N.A. 6.6 13.3 0 6.6 N.A. 20 6.6 N.A. 6.6
P-Site Similarity: 100 46.6 93.3 33.3 N.A. 86.6 13.3 N.A. 33.3 40 13.3 26.6 N.A. 26.6 6.6 N.A. 13.3
Percent
Protein Identity: N.A. 31.3 N.A. 28.1 N.A. N.A.
Protein Similarity: N.A. 45 N.A. 41.2 N.A. N.A.
P-Site Identity: N.A. 13.3 N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. 33.3 N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 14 0 7 7 14 7 7 20 14 20 20 20 0 27 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 0 0 7 0 0 0 7 0 0 14 0 7 0 7 0 % D
% Glu: 7 0 7 0 0 0 7 0 0 14 0 14 7 0 14 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 0 7 0 0 7 0 0 0 0 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 7 7 0 0 0 0 0 0 % H
% Ile: 7 0 14 0 0 0 0 0 0 7 14 0 0 0 7 % I
% Lys: 7 0 0 0 14 0 0 7 0 0 27 0 7 7 7 % K
% Leu: 0 0 0 20 0 0 14 14 7 7 0 14 14 14 0 % L
% Met: 0 0 0 0 0 7 0 7 7 0 0 0 0 20 0 % M
% Asn: 0 7 0 0 7 0 0 0 0 7 7 14 0 0 7 % N
% Pro: 14 0 27 27 0 34 20 20 27 20 0 7 14 34 0 % P
% Gln: 0 40 0 0 0 0 7 14 0 20 7 0 0 7 7 % Q
% Arg: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % R
% Ser: 54 7 27 20 20 20 7 7 7 0 14 27 14 0 7 % S
% Thr: 0 20 7 0 40 27 14 20 14 0 7 0 27 7 20 % T
% Val: 7 7 14 14 7 0 14 0 7 0 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _