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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3C All Species: 16.06
Human Site: S312 Identified Species: 25.24
UniProt: Q15386 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15386 NP_055486.2 1083 123923 S312 E S R C S R K S G G A P W L F
Chimpanzee Pan troglodytes XP_528010 1089 124652 S318 E S R C S R K S G G A P W L F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539937 1088 124202 S316 S G T S S R T S S R A P W L F
Cat Felis silvestris
Mouse Mus musculus Q80U95 1083 123957 C312 E S Q S S K R C S G V P W L F
Rat Rattus norvegicus Q62940 887 102376 L187 Y T F K D F V L H P R S H K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510756 1084 124281 S312 E S K R S R K S D R A P W L F
Chicken Gallus gallus NP_001026138 1084 124128 S312 E N G C S R K S D R A P W L F
Frog Xenopus laevis Q6DCL5 944 106566 T244 V Q G G Y G E T C D I L I Q H
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 Y65 D P K W N Q H Y D L Y I G K S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611896 1122 128925 V346 F L L N S L M V L D R R Q L A
Honey Bee Apis mellifera XP_396547 1033 119022 D304 L S A C K S K D I L I N Y L Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797123 1037 118587 L310 D L V I R Y L L L L K I L L P
Poplar Tree Populus trichocarpa XP_002314972 1027 117409 I300 R G L S Q H Y I H Q M A Q C V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWB8 1029 117643 Q301 L S Q H Y I H Q M A S C I Q K
Baker's Yeast Sacchar. cerevisiae P53119 910 105547 R210 F Y C I L A E R N L L P Q L I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.8 N.A. 95.4 N.A. 93.3 22.1 N.A. 91.4 90.6 22.8 22.5 N.A. 39.7 43 N.A. 44.2
Protein Similarity: 100 98.1 N.A. 97.4 N.A. 97.2 38.4 N.A. 95.6 94.8 39 38.3 N.A. 61 62.7 N.A. 61.6
P-Site Identity: 100 100 N.A. 53.3 N.A. 53.3 0 N.A. 73.3 73.3 0 0 N.A. 13.3 26.6 N.A. 6.6
P-Site Similarity: 100 100 N.A. 53.3 N.A. 73.3 6.6 N.A. 80 80 13.3 26.6 N.A. 13.3 33.3 N.A. 13.3
Percent
Protein Identity: 28.3 N.A. N.A. 28.7 26.7 N.A.
Protein Similarity: 47 N.A. N.A. 49 44.9 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: 0 N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 7 0 0 0 7 34 7 0 0 7 % A
% Cys: 0 0 7 27 0 0 0 7 7 0 0 7 0 7 0 % C
% Asp: 14 0 0 0 7 0 0 7 20 14 0 0 0 0 0 % D
% Glu: 34 0 0 0 0 0 14 0 0 0 0 0 0 0 0 % E
% Phe: 14 0 7 0 0 7 0 0 0 0 0 0 0 0 40 % F
% Gly: 0 14 14 7 0 7 0 0 14 20 0 0 7 0 0 % G
% His: 0 0 0 7 0 7 14 0 14 0 0 0 7 0 7 % H
% Ile: 0 0 0 14 0 7 0 7 7 0 14 14 14 0 7 % I
% Lys: 0 0 14 7 7 7 34 0 0 0 7 0 0 14 7 % K
% Leu: 14 14 14 0 7 7 7 14 14 27 7 7 7 67 0 % L
% Met: 0 0 0 0 0 0 7 0 7 0 7 0 0 0 0 % M
% Asn: 0 7 0 7 7 0 0 0 7 0 0 7 0 0 0 % N
% Pro: 0 7 0 0 0 0 0 0 0 7 0 47 0 0 7 % P
% Gln: 0 7 14 0 7 7 0 7 0 7 0 0 20 14 7 % Q
% Arg: 7 0 14 7 7 34 7 7 0 20 14 7 0 0 0 % R
% Ser: 7 40 0 20 47 7 0 34 14 0 7 7 0 0 14 % S
% Thr: 0 7 7 0 0 0 7 7 0 0 0 0 0 0 0 % T
% Val: 7 0 7 0 0 0 7 7 0 0 7 0 0 0 7 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 40 0 0 % W
% Tyr: 7 7 0 0 14 7 7 7 0 0 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _