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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3C All Species: 24.85
Human Site: S493 Identified Species: 39.05
UniProt: Q15386 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15386 NP_055486.2 1083 123923 S493 S P M S F E D S S R I I P L F
Chimpanzee Pan troglodytes XP_528010 1089 124652 S499 S P M S F E D S S R I I P L F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539937 1088 124202 S498 S P M S L E D S S R I I P L F
Cat Felis silvestris
Mouse Mus musculus Q80U95 1083 123957 S493 S P M S F E D S S R I I P L F
Rat Rattus norvegicus Q62940 887 102376 A366 L T M Y G N P A T S Q P V T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510756 1084 124281 S494 S P M S L E D S S R I I P L F
Chicken Gallus gallus NP_001026138 1084 124128 S494 S P M S L D E S S R I I P L F
Frog Xenopus laevis Q6DCL5 944 106566 I423 D S S N I A C I L L K Q S P L
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 R244 R H R N Y M S R T H L H T P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611896 1122 128925 T539 K H Q G V D R T I P L L A T F
Honey Bee Apis mellifera XP_396547 1033 119022 I487 I Q D Q S L D I N G Q Q A M P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797123 1037 118587 S490 F Y G D D A D S N R N S L M P
Poplar Tree Populus trichocarpa XP_002314972 1027 117409 P481 C H E N K K W P S L P E Q L S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWB8 1029 117643 N480 Y M K R C H E N Q K W S S M P
Baker's Yeast Sacchar. cerevisiae P53119 910 105547 R389 T L K D F T F R Q Y W E L P K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.8 N.A. 95.4 N.A. 93.3 22.1 N.A. 91.4 90.6 22.8 22.5 N.A. 39.7 43 N.A. 44.2
Protein Similarity: 100 98.1 N.A. 97.4 N.A. 97.2 38.4 N.A. 95.6 94.8 39 38.3 N.A. 61 62.7 N.A. 61.6
P-Site Identity: 100 100 N.A. 93.3 N.A. 100 6.6 N.A. 93.3 80 0 0 N.A. 6.6 6.6 N.A. 20
P-Site Similarity: 100 100 N.A. 93.3 N.A. 100 20 N.A. 93.3 93.3 6.6 26.6 N.A. 33.3 20 N.A. 33.3
Percent
Protein Identity: 28.3 N.A. N.A. 28.7 26.7 N.A.
Protein Similarity: 47 N.A. N.A. 49 44.9 N.A.
P-Site Identity: 13.3 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 14 0 7 0 0 0 0 14 0 0 % A
% Cys: 7 0 0 0 7 0 7 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 7 14 7 14 47 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 7 0 0 34 14 0 0 0 0 14 0 0 0 % E
% Phe: 7 0 0 0 27 0 7 0 0 0 0 0 0 0 47 % F
% Gly: 0 0 7 7 7 0 0 0 0 7 0 0 0 0 0 % G
% His: 0 20 0 0 0 7 0 0 0 7 0 7 0 0 0 % H
% Ile: 7 0 0 0 7 0 0 14 7 0 40 40 0 0 0 % I
% Lys: 7 0 14 0 7 7 0 0 0 7 7 0 0 0 7 % K
% Leu: 7 7 0 0 20 7 0 0 7 14 14 7 14 47 7 % L
% Met: 0 7 47 0 0 7 0 0 0 0 0 0 0 20 0 % M
% Asn: 0 0 0 20 0 7 0 7 14 0 7 0 0 0 0 % N
% Pro: 0 40 0 0 0 0 7 7 0 7 7 7 40 20 27 % P
% Gln: 0 7 7 7 0 0 0 0 14 0 14 14 7 0 0 % Q
% Arg: 7 0 7 7 0 0 7 14 0 47 0 0 0 0 0 % R
% Ser: 40 7 7 40 7 0 7 47 47 7 0 14 14 0 14 % S
% Thr: 7 7 0 0 0 7 0 7 14 0 0 0 7 14 0 % T
% Val: 0 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 14 0 0 0 0 % W
% Tyr: 7 7 0 7 7 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _