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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3C All Species: 22.73
Human Site: T617 Identified Species: 35.71
UniProt: Q15386 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15386 NP_055486.2 1083 123923 T617 K M L K S R D T R R N F C P P
Chimpanzee Pan troglodytes XP_528010 1089 124652 T623 K M L K S R D T R R N F C P P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539937 1088 124202 T622 K M L K S R D T R R N F C P P
Cat Felis silvestris
Mouse Mus musculus Q80U95 1083 123957 T617 K M L K S R D T R R N F C P P
Rat Rattus norvegicus Q62940 887 102376 H480 G R V F F I N H N I K K T Q W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510756 1084 124281 T618 K M L K S R D T R R N F C P P
Chicken Gallus gallus NP_001026138 1084 124128 T618 K M L K A R D T R R N F C P P
Frog Xenopus laevis Q6DCL5 944 106566 F537 P K I I F D H F H F L L E C P
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 G358 A Q S S S R P G Q L K E Q A Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611896 1122 128925 L657 N Q I H T R D L R L G F C P E
Honey Bee Apis mellifera XP_396547 1033 119022 L601 F T F R R R R L R G Y I P F Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797123 1037 118587 G606 S R G V R G H G G R M Y R P R
Poplar Tree Populus trichocarpa XP_002314972 1027 117409 N595 S Q L Q D W N N R R Q F A P P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWB8 1029 117643 N597 S Q L Q D W N N R K Q F T S S
Baker's Yeast Sacchar. cerevisiae P53119 910 105547 I503 L R F R K L E I L L E L P F F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.8 N.A. 95.4 N.A. 93.3 22.1 N.A. 91.4 90.6 22.8 22.5 N.A. 39.7 43 N.A. 44.2
Protein Similarity: 100 98.1 N.A. 97.4 N.A. 97.2 38.4 N.A. 95.6 94.8 39 38.3 N.A. 61 62.7 N.A. 61.6
P-Site Identity: 100 100 N.A. 100 N.A. 100 0 N.A. 100 93.3 6.6 13.3 N.A. 40 13.3 N.A. 13.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 13.3 N.A. 100 100 13.3 20 N.A. 53.3 20 N.A. 20
Percent
Protein Identity: 28.3 N.A. N.A. 28.7 26.7 N.A.
Protein Similarity: 47 N.A. N.A. 49 44.9 N.A.
P-Site Identity: 40 N.A. N.A. 20 0 N.A.
P-Site Similarity: 53.3 N.A. N.A. 40 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 7 0 0 0 0 0 0 0 7 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 47 7 0 % C
% Asp: 0 0 0 0 14 7 47 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 7 0 0 0 7 7 7 0 7 % E
% Phe: 7 0 14 7 14 0 0 7 0 7 0 60 0 14 7 % F
% Gly: 7 0 7 0 0 7 0 14 7 7 7 0 0 0 0 % G
% His: 0 0 0 7 0 0 14 7 7 0 0 0 0 0 0 % H
% Ile: 0 0 14 7 0 7 0 7 0 7 0 7 0 0 0 % I
% Lys: 40 7 0 40 7 0 0 0 0 7 14 7 0 0 0 % K
% Leu: 7 0 54 0 0 7 0 14 7 20 7 14 0 0 0 % L
% Met: 0 40 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 20 14 7 0 40 0 0 0 0 % N
% Pro: 7 0 0 0 0 0 7 0 0 0 0 0 14 60 54 % P
% Gln: 0 27 0 14 0 0 0 0 7 0 14 0 7 7 14 % Q
% Arg: 0 20 0 14 14 60 7 0 67 54 0 0 7 0 7 % R
% Ser: 20 0 7 7 40 0 0 0 0 0 0 0 0 7 7 % S
% Thr: 0 7 0 0 7 0 0 40 0 0 0 0 14 0 0 % T
% Val: 0 0 7 7 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 14 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _