Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SF3B3 All Species: 40.91
Human Site: T683 Identified Species: 60
UniProt: Q15393 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15393 NP_036558.3 1217 135577 T683 R T V L D P V T G D L S D T R
Chimpanzee Pan troglodytes XP_511081 1283 142840 T749 R T V L D P V T G D L S D T R
Rhesus Macaque Macaca mulatta XP_001107025 1199 133593 T665 R T V L D P V T G D L S D T R
Dog Lupus familis XP_536791 1217 135545 T683 R T V L D P V T G D L S D T R
Cat Felis silvestris
Mouse Mus musculus Q921M3 1217 135532 T683 R T V L D P V T G D L S D T R
Rat Rattus norvegicus XP_001077410 1216 135436 T682 R T V L D P V T G D L S D T R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506454 1217 135474 T683 R T V L D P V T G D L S D T R
Chicken Gallus gallus XP_001232348 1218 135585 T683 R T V L D P V T G D L S D T R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1LVE8 1217 135603 T683 R T V L D P V T G D L S D T R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728546 1227 136598 L683 I G L S N G V L L R T V L D P
Honey Bee Apis mellifera XP_623333 1217 135272 S683 R T V L D P I S G D L A D T R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188711 1141 126889 F653 S Y W Y Q S R F H L T P L S Y
Poplar Tree Populus trichocarpa XP_002312063 1213 134429 Q680 V V D M V T G Q L S D S R S R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O49552 1088 121161 C614 N F Q L D T S C G K L R D R K
Baker's Yeast Sacchar. cerevisiae Q04693 1361 153766 D759 K F H I G D V D G S F T D I K
Red Bread Mold Neurospora crassa Q7RYR4 1209 134021 K701 E L T D T R Q K F L G P K P T
Conservation
Percent
Protein Identity: 100 94.8 98.1 99.9 N.A. 99.9 99.5 N.A. 99.6 99 N.A. 93.4 N.A. 75.4 80.5 N.A. 76.1
Protein Similarity: 100 94.8 98.2 100 N.A. 100 99.5 N.A. 99.9 99.6 N.A. 97.9 N.A. 86.9 90.2 N.A. 85.7
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 100 N.A. 6.6 80 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 100 N.A. 20 100 N.A. 6.6
Percent
Protein Identity: 58.7 N.A. N.A. 23.5 23 51
Protein Similarity: 76.1 N.A. N.A. 42 41.5 69.5
P-Site Identity: 13.3 N.A. N.A. 33.3 20 0
P-Site Similarity: 26.6 N.A. N.A. 40 46.6 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 7 69 7 0 7 0 63 7 0 75 7 0 % D
% Glu: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 13 0 0 0 0 0 7 7 0 7 0 0 0 0 % F
% Gly: 0 7 0 0 7 7 7 0 75 0 7 0 0 0 0 % G
% His: 0 0 7 0 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 7 0 0 7 0 0 7 0 0 0 0 0 0 7 0 % I
% Lys: 7 0 0 0 0 0 0 7 0 7 0 0 7 0 13 % K
% Leu: 0 7 7 69 0 0 0 7 13 13 69 0 13 0 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 63 0 0 0 0 0 13 0 7 7 % P
% Gln: 0 0 7 0 7 0 7 7 0 0 0 0 0 0 0 % Q
% Arg: 63 0 0 0 0 7 7 0 0 7 0 7 7 7 69 % R
% Ser: 7 0 0 7 0 7 7 7 0 13 0 63 0 13 0 % S
% Thr: 0 63 7 0 7 13 0 57 0 0 13 7 0 63 7 % T
% Val: 7 7 63 0 7 0 69 0 0 0 0 7 0 0 0 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _