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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SF3B4 All Species: 18.18
Human Site: S219 Identified Species: 36.36
UniProt: Q15427 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15427 NP_005841.1 424 44386 S219 A D A P P P P S A P N P V V S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta Q7JGR2 382 43298 T225 L F C E Y G P T E S V K V I R
Dog Lupus familis XP_540295 409 42782 S219 A D A P P P P S A P N P V V S
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus Q6AYL5 424 44337 S219 A D A P P P P S A P N P V V S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423721 418 43905 S219 A D A P P P P S V P T P V V T
Frog Xenopus laevis P20965 633 70449 A440 P R W T A Q G A R P H P F Q N
Zebra Danio Brachydanio rerio NP_705947 400 41939 S219 A D A P P P P S M P T P V M T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393914 413 44283 P221 A P P L A P P P I P N S N T A
Nematode Worm Caenorhab. elegans Q09442 388 40990 A220 D V P L G V P A N T P L A M P
Sea Urchin Strong. purpuratus XP_784135 425 45156 P249 S N V P T S N P L P M P P P F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42731 629 68654 Q316 K E A A D K F Q S S N L Y V K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S6N6 764 82299 M575 P P N T P Q Y M A A M G Q V G
Conservation
Percent
Protein Identity: 100 N.A. 24.2 95.7 N.A. N.A. 99.5 N.A. N.A. 89.8 20.5 80.6 N.A. N.A. 62.9 58.9 67.2
Protein Similarity: 100 N.A. 37 95.9 N.A. N.A. 99.7 N.A. N.A. 91.9 32.7 83.9 N.A. N.A. 69.5 66.7 72.4
P-Site Identity: 100 N.A. 13.3 100 N.A. N.A. 100 N.A. N.A. 80 13.3 73.3 N.A. N.A. 33.3 6.6 20
P-Site Similarity: 100 N.A. 26.6 100 N.A. N.A. 100 N.A. N.A. 86.6 33.3 86.6 N.A. N.A. 40 20 33.3
Percent
Protein Identity: N.A. N.A. N.A. 24.1 N.A. 20.4
Protein Similarity: N.A. N.A. N.A. 32.7 N.A. 31
P-Site Identity: N.A. N.A. N.A. 20 N.A. 20
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 50 0 50 9 17 0 0 17 34 9 0 0 9 0 9 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 42 0 0 9 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 9 0 9 0 0 0 0 9 0 0 0 0 0 0 % E
% Phe: 0 9 0 0 0 0 9 0 0 0 0 0 9 0 9 % F
% Gly: 0 0 0 0 9 9 9 0 0 0 0 9 0 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 0 % I
% Lys: 9 0 0 0 0 9 0 0 0 0 0 9 0 0 9 % K
% Leu: 9 0 0 17 0 0 0 0 9 0 0 17 0 0 0 % L
% Met: 0 0 0 0 0 0 0 9 9 0 17 0 0 17 0 % M
% Asn: 0 9 9 0 0 0 9 0 9 0 42 0 9 0 9 % N
% Pro: 17 17 17 50 50 50 67 17 0 67 9 59 9 9 9 % P
% Gln: 0 0 0 0 0 17 0 9 0 0 0 0 9 9 0 % Q
% Arg: 0 9 0 0 0 0 0 0 9 0 0 0 0 0 9 % R
% Ser: 9 0 0 0 0 9 0 42 9 17 0 9 0 0 25 % S
% Thr: 0 0 0 17 9 0 0 9 0 9 17 0 0 9 17 % T
% Val: 0 9 9 0 0 9 0 0 9 0 9 0 50 50 0 % V
% Trp: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 9 0 9 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _