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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SHB All Species: 4.24
Human Site: S38 Identified Species: 13.33
UniProt: Q15464 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15464 NP_003019.2 509 55042 S38 R R R G E R P S Q P P Q A V P
Chimpanzee Pan troglodytes XP_001146974 435 47987
Rhesus Macaque Macaca mulatta XP_001111408 422 46812
Dog Lupus familis XP_538741 623 67323 S153 R R R G E R P S Q A P Q A V P
Cat Felis silvestris
Mouse Mus musculus Q6PD21 503 54689 E38 R R R G E R R E Q P P Q A V P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511560 269 30754
Chicken Gallus gallus
Frog Xenopus laevis Q8UUU2 722 83110 G142 I E A I E K K G L E S A T L Y
Zebra Danio Brachydanio rerio NP_001038542 391 44295
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 31.6 32.8 78.9 N.A. 92.9 N.A. N.A. 47.1 N.A. 20.3 41.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 43.6 45.5 79.6 N.A. 95.4 N.A. N.A. 50.6 N.A. 34.3 52 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 0 93.3 N.A. 86.6 N.A. N.A. 0 N.A. 6.6 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 0 0 93.3 N.A. 86.6 N.A. N.A. 0 N.A. 20 0 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 13 0 0 0 0 0 0 13 0 13 38 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 13 0 0 50 0 0 13 0 13 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 38 0 0 0 13 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 13 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 13 13 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 13 0 0 0 0 13 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 25 0 0 25 38 0 0 0 38 % P
% Gln: 0 0 0 0 0 0 0 0 38 0 0 38 0 0 0 % Q
% Arg: 38 38 38 0 0 38 13 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 25 0 0 13 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 38 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _