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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHH
All Species:
9.09
Human Site:
S135
Identified Species:
20
UniProt:
Q15465
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15465
NP_000184.1
462
49607
S135
W
D
E
D
G
H
H
S
E
E
S
L
H
Y
E
Chimpanzee
Pan troglodytes
XP_001147185
383
41284
E71
G
K
I
S
R
N
S
E
R
F
K
E
L
T
P
Rhesus Macaque
Macaca mulatta
XP_001106515
462
49937
S135
W
D
E
D
G
H
H
S
E
E
S
L
H
Y
E
Dog
Lupus familis
XP_850450
461
49637
S135
W
D
E
D
G
H
H
S
E
E
S
L
H
Y
E
Cat
Felis silvestris
Mouse
Mus musculus
Q62226
437
47755
R124
Q
W
P
G
V
K
L
R
V
T
E
G
W
D
E
Rat
Rattus norvegicus
Q63673
437
47612
R124
Q
W
P
G
V
K
L
R
V
T
E
G
W
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q91035
425
46456
A113
K
D
K
L
N
A
L
A
I
S
V
M
N
Q
W
Frog
Xenopus laevis
Q92000
444
49435
E127
G
V
K
L
R
V
T
E
G
W
D
E
D
G
H
Zebra Danio
Brachydanio rerio
Q90419
416
46558
K103
N
A
D
R
L
M
T
K
R
C
K
D
K
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02936
471
52132
R127
G
P
L
E
G
V
I
R
R
D
S
P
K
F
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001012720
411
46240
R99
K
E
G
T
G
A
D
R
L
M
T
Q
R
C
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
80
96.7
93.2
N.A.
88
88
N.A.
N.A.
77.9
66.6
62.9
N.A.
44.3
N.A.
N.A.
46.5
Protein Similarity:
100
81.5
96.9
94.1
N.A.
89.8
89.6
N.A.
N.A.
83.9
75.7
72.7
N.A.
58.3
N.A.
N.A.
59.3
P-Site Identity:
100
0
100
100
N.A.
6.6
6.6
N.A.
N.A.
6.6
0
0
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
6.6
100
100
N.A.
6.6
6.6
N.A.
N.A.
33.3
6.6
6.6
N.A.
40
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
19
0
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% C
% Asp:
0
37
10
28
0
0
10
0
0
10
10
10
10
19
0
% D
% Glu:
0
10
28
10
0
0
0
19
28
28
19
19
0
0
46
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% F
% Gly:
28
0
10
19
46
0
0
0
10
0
0
19
0
10
0
% G
% His:
0
0
0
0
0
28
28
0
0
0
0
0
28
0
10
% H
% Ile:
0
0
10
0
0
0
10
0
10
0
0
0
0
0
0
% I
% Lys:
19
10
19
0
0
19
0
10
0
0
19
0
19
0
19
% K
% Leu:
0
0
10
19
10
0
28
0
10
0
0
28
10
10
0
% L
% Met:
0
0
0
0
0
10
0
0
0
10
0
10
0
0
0
% M
% Asn:
10
0
0
0
10
10
0
0
0
0
0
0
10
0
10
% N
% Pro:
0
10
19
0
0
0
0
0
0
0
0
10
0
0
10
% P
% Gln:
19
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% Q
% Arg:
0
0
0
10
19
0
0
37
28
0
0
0
10
0
0
% R
% Ser:
0
0
0
10
0
0
10
28
0
10
37
0
0
0
0
% S
% Thr:
0
0
0
10
0
0
19
0
0
19
10
0
0
10
0
% T
% Val:
0
10
0
0
19
19
0
0
19
0
10
0
0
0
0
% V
% Trp:
28
19
0
0
0
0
0
0
0
10
0
0
19
0
10
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
28
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _