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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHH
All Species:
8.48
Human Site:
S280
Identified Species:
18.67
UniProt:
Q15465
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15465
NP_000184.1
462
49607
S280
F
V
A
P
H
N
D
S
A
T
G
E
P
E
A
Chimpanzee
Pan troglodytes
XP_001147185
383
41284
L214
L
E
Q
G
G
T
K
L
V
K
D
L
S
P
G
Rhesus Macaque
Macaca mulatta
XP_001106515
462
49937
S280
F
V
A
P
H
N
D
S
A
A
A
E
P
E
A
Dog
Lupus familis
XP_850450
461
49637
S280
F
V
A
P
L
N
D
S
A
A
G
E
P
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q62226
437
47755
L267
E
P
R
E
R
L
L
L
T
A
A
H
L
L
F
Rat
Rattus norvegicus
Q63673
437
47612
L267
E
P
R
E
R
L
L
L
T
A
A
H
L
L
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q91035
425
46456
Y256
D
S
S
R
K
L
F
Y
V
I
E
T
R
Q
P
Frog
Xenopus laevis
Q92000
444
49435
L271
R
L
T
A
A
H
L
L
F
V
A
Q
T
K
V
Zebra Danio
Brachydanio rerio
Q90419
416
46558
D246
S
D
F
I
M
F
I
D
H
D
P
T
T
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02936
471
52132
P274
L
E
S
G
V
R
K
P
L
G
E
L
S
I
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001012720
411
46240
M242
L
D
Y
S
D
V
I
M
I
V
H
R
K
L
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
80
96.7
93.2
N.A.
88
88
N.A.
N.A.
77.9
66.6
62.9
N.A.
44.3
N.A.
N.A.
46.5
Protein Similarity:
100
81.5
96.9
94.1
N.A.
89.8
89.6
N.A.
N.A.
83.9
75.7
72.7
N.A.
58.3
N.A.
N.A.
59.3
P-Site Identity:
100
0
86.6
86.6
N.A.
0
0
N.A.
N.A.
0
0
0
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
0
86.6
86.6
N.A.
0
0
N.A.
N.A.
13.3
26.6
0
N.A.
6.6
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
28
10
10
0
0
0
28
37
37
0
0
0
28
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
19
0
0
10
0
28
10
0
10
10
0
0
0
0
% D
% Glu:
19
19
0
19
0
0
0
0
0
0
19
28
0
28
0
% E
% Phe:
28
0
10
0
0
10
10
0
10
0
0
0
0
0
19
% F
% Gly:
0
0
0
19
10
0
0
0
0
10
19
0
0
0
19
% G
% His:
0
0
0
0
19
10
0
0
10
0
10
19
0
0
0
% H
% Ile:
0
0
0
10
0
0
19
0
10
10
0
0
0
10
0
% I
% Lys:
0
0
0
0
10
0
19
0
0
10
0
0
10
10
0
% K
% Leu:
28
10
0
0
10
28
28
37
10
0
0
19
19
28
0
% L
% Met:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
28
0
0
0
0
0
0
0
0
10
% N
% Pro:
0
19
0
28
0
0
0
10
0
0
10
0
28
10
10
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
0
10
0
10
0
% Q
% Arg:
10
0
19
10
19
10
0
0
0
0
0
10
10
10
10
% R
% Ser:
10
10
19
10
0
0
0
28
0
0
0
0
19
0
0
% S
% Thr:
0
0
10
0
0
10
0
0
19
10
0
19
19
0
0
% T
% Val:
0
28
0
0
10
10
0
0
19
19
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _