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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHH
All Species:
22.42
Human Site:
S449
Identified Species:
49.33
UniProt:
Q15465
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15465
NP_000184.1
462
49607
S449
I
G
T
W
L
L
D
S
E
A
L
H
P
L
G
Chimpanzee
Pan troglodytes
XP_001147185
383
41284
E371
G
T
W
L
L
D
S
E
A
L
H
P
L
G
M
Rhesus Macaque
Macaca mulatta
XP_001106515
462
49937
S449
I
G
T
W
L
L
D
S
E
A
L
H
P
L
G
Dog
Lupus familis
XP_850450
461
49637
S448
I
G
T
W
L
L
D
S
E
A
L
H
P
L
G
Cat
Felis silvestris
Mouse
Mus musculus
Q62226
437
47755
S424
I
G
T
W
L
L
D
S
E
T
M
H
P
L
G
Rat
Rattus norvegicus
Q63673
437
47612
S424
I
G
T
W
L
L
D
S
E
T
L
H
P
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q91035
425
46456
D413
G
S
W
V
L
D
G
D
A
L
H
P
L
G
M
Frog
Xenopus laevis
Q92000
444
49435
S431
I
G
T
W
L
L
D
S
N
S
L
H
P
L
G
Zebra Danio
Brachydanio rerio
Q90419
416
46558
R404
I
G
S
W
L
L
D
R
D
S
F
H
P
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02936
471
52132
A455
G
I
H
W
Y
A
N
A
L
Y
K
V
K
D
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001012720
411
46240
Y399
R
L
Y
K
L
G
K
Y
V
M
S
D
R
L
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
80
96.7
93.2
N.A.
88
88
N.A.
N.A.
77.9
66.6
62.9
N.A.
44.3
N.A.
N.A.
46.5
Protein Similarity:
100
81.5
96.9
94.1
N.A.
89.8
89.6
N.A.
N.A.
83.9
75.7
72.7
N.A.
58.3
N.A.
N.A.
59.3
P-Site Identity:
100
6.6
100
100
N.A.
86.6
93.3
N.A.
N.A.
6.6
86.6
66.6
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
N.A.
6.6
93.3
86.6
N.A.
20
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
10
19
28
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
19
64
10
10
0
0
10
0
10
0
% D
% Glu:
0
0
0
0
0
0
0
10
46
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% F
% Gly:
28
64
0
0
0
10
10
0
0
0
0
0
0
19
64
% G
% His:
0
0
10
0
0
0
0
0
0
0
19
64
0
0
0
% H
% Ile:
64
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
0
0
10
0
0
0
10
0
10
0
0
% K
% Leu:
0
10
0
10
91
64
0
0
10
19
46
0
19
73
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
19
% M
% Asn:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
19
64
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
0
10
0
0
0
0
10
0
0
% R
% Ser:
0
10
10
0
0
0
10
55
0
19
10
0
0
0
0
% S
% Thr:
0
10
55
0
0
0
0
0
0
19
0
0
0
0
0
% T
% Val:
0
0
0
10
0
0
0
0
10
0
0
10
0
0
0
% V
% Trp:
0
0
19
73
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
10
0
0
10
0
10
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _