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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHH
All Species:
6.06
Human Site:
T395
Identified Species:
13.33
UniProt:
Q15465
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15465
NP_000184.1
462
49607
T395
A
A
L
A
P
A
R
T
D
R
G
G
D
S
G
Chimpanzee
Pan troglodytes
XP_001147185
383
41284
V317
N
S
K
P
H
V
T
V
R
G
G
T
R
S
P
Rhesus Macaque
Macaca mulatta
XP_001106515
462
49937
T395
A
A
L
A
P
A
R
T
D
R
G
G
D
S
G
Dog
Lupus familis
XP_850450
461
49637
R394
L
A
A
L
A
P
A
R
T
D
R
G
G
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q62226
437
47755
H370
F
A
P
F
R
L
A
H
A
L
L
A
A
L
A
Rat
Rattus norvegicus
Q63673
437
47612
H370
F
A
P
F
R
L
A
H
A
L
L
A
A
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q91035
425
46456
H359
C
Y
A
V
I
E
E
H
S
W
A
H
W
A
F
Frog
Xenopus laevis
Q92000
444
49435
P377
I
Y
P
R
D
S
S
P
P
S
G
L
Q
P
H
Zebra Danio
Brachydanio rerio
Q90419
416
46558
E350
A
S
C
Y
A
V
I
E
N
H
K
W
A
H
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02936
471
52132
Y401
N
S
V
A
A
S
C
Y
A
V
I
N
S
Q
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001012720
411
46240
S345
I
D
D
V
A
I
S
S
Y
A
V
M
R
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
80
96.7
93.2
N.A.
88
88
N.A.
N.A.
77.9
66.6
62.9
N.A.
44.3
N.A.
N.A.
46.5
Protein Similarity:
100
81.5
96.9
94.1
N.A.
89.8
89.6
N.A.
N.A.
83.9
75.7
72.7
N.A.
58.3
N.A.
N.A.
59.3
P-Site Identity:
100
13.3
100
20
N.A.
6.6
6.6
N.A.
N.A.
0
6.6
6.6
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
20
100
20
N.A.
6.6
6.6
N.A.
N.A.
6.6
13.3
20
N.A.
26.6
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
46
19
28
37
19
28
0
28
10
10
19
28
10
19
% A
% Cys:
10
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
10
0
10
0
0
0
19
10
0
0
19
10
0
% D
% Glu:
0
0
0
0
0
10
10
10
0
0
0
0
0
10
10
% E
% Phe:
19
0
0
19
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
37
28
10
0
28
% G
% His:
0
0
0
0
10
0
0
28
0
10
0
10
0
10
10
% H
% Ile:
19
0
0
0
10
10
10
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
0
% K
% Leu:
10
0
19
10
0
19
0
0
0
19
19
10
0
19
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
19
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% N
% Pro:
0
0
28
10
19
10
0
10
10
0
0
0
0
10
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% Q
% Arg:
0
0
0
10
19
0
19
10
10
19
10
0
19
0
0
% R
% Ser:
0
28
0
0
0
19
19
10
10
10
0
0
10
28
10
% S
% Thr:
0
0
0
0
0
0
10
19
10
0
0
10
0
0
0
% T
% Val:
0
0
10
19
0
19
0
10
0
10
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
0
10
10
0
10
% W
% Tyr:
0
19
0
10
0
0
0
10
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _