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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX1
All Species:
43.94
Human Site:
S135
Identified Species:
80.56
UniProt:
Q15475
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15475
NP_005973.1
284
32210
S135
S
Y
C
F
K
E
K
S
R
G
V
L
R
E
W
Chimpanzee
Pan troglodytes
XP_515444
293
32560
S135
S
Y
C
F
K
E
K
S
R
S
V
L
R
E
W
Rhesus Macaque
Macaca mulatta
XP_001096585
284
32192
S135
S
Y
C
F
K
E
K
S
R
G
V
L
R
E
W
Dog
Lupus familis
XP_547841
714
77250
S565
S
Y
C
F
K
E
K
S
R
G
V
L
R
E
W
Cat
Felis silvestris
Mouse
Mus musculus
Q62231
284
32192
S135
S
Y
C
F
K
E
K
S
R
G
V
L
R
E
W
Rat
Rattus norvegicus
NP_446211
284
32192
S135
S
Y
C
F
K
E
K
S
R
G
V
L
R
E
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505983
285
31909
S135
S
Y
C
F
K
E
K
S
R
S
V
L
R
E
W
Chicken
Gallus gallus
O42406
314
34658
P166
A
E
K
L
R
G
R
P
L
G
P
V
D
K
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_996978
284
31956
S135
S
Y
C
F
K
E
K
S
R
G
V
L
R
E
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
S229
S
Y
C
F
K
E
K
S
R
S
V
L
R
D
W
Honey Bee
Apis mellifera
XP_396811
512
55470
S211
S
Y
C
F
K
E
K
S
R
S
V
L
R
D
W
Nematode Worm
Caenorhab. elegans
Q94166
261
30692
K117
R
Q
L
G
A
V
G
K
Y
R
I
R
R
K
Y
Sea Urchin
Strong. purpuratus
XP_781551
476
53123
S273
S
Y
C
F
K
E
K
S
R
S
I
L
R
E
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.4
99.3
39.6
N.A.
99.3
99.3
N.A.
76.1
48
N.A.
91.9
N.A.
44.4
41.4
45.7
43.7
Protein Similarity:
100
81.5
99.3
39.6
N.A.
99.3
99.3
N.A.
84.2
62.7
N.A.
95.4
N.A.
53.1
48.2
62.6
49.5
P-Site Identity:
100
93.3
100
100
N.A.
100
100
N.A.
93.3
6.6
N.A.
100
N.A.
86.6
86.6
6.6
86.6
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
93.3
46.6
N.A.
100
N.A.
93.3
93.3
26.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
85
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
8
16
0
% D
% Glu:
0
8
0
0
0
85
0
0
0
0
0
0
0
70
0
% E
% Phe:
0
0
0
85
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
8
8
0
0
54
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% I
% Lys:
0
0
8
0
85
0
85
8
0
0
0
0
0
16
0
% K
% Leu:
0
0
8
8
0
0
0
0
8
0
0
85
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
8
0
8
0
85
8
0
8
93
0
0
% R
% Ser:
85
0
0
0
0
0
0
85
0
39
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
77
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
85
% W
% Tyr:
0
85
0
0
0
0
0
0
8
0
0
0
0
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _