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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX1
All Species:
26.67
Human Site:
S221
Identified Species:
48.89
UniProt:
Q15475
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15475
NP_005973.1
284
32210
S221
S
S
S
E
E
E
F
S
P
P
Q
S
P
D
Q
Chimpanzee
Pan troglodytes
XP_515444
293
32560
S230
T
P
D
H
S
S
S
S
P
A
L
L
L
S
P
Rhesus Macaque
Macaca mulatta
XP_001096585
284
32192
S221
S
S
S
E
E
E
F
S
P
P
Q
S
P
D
Q
Dog
Lupus familis
XP_547841
714
77250
S651
S
S
S
E
E
E
F
S
P
P
Q
S
P
D
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q62231
284
32192
S221
S
S
S
E
E
E
F
S
P
P
Q
S
P
D
Q
Rat
Rattus norvegicus
NP_446211
284
32192
S221
S
S
S
E
E
E
F
S
P
P
Q
S
P
D
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505983
285
31909
T218
G
S
S
E
D
E
K
T
P
S
G
T
P
N
H
Chicken
Gallus gallus
O42406
314
34658
L252
A
A
A
A
K
N
R
L
Q
H
Q
A
I
G
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_996978
284
31956
S221
S
S
S
E
D
E
F
S
P
P
Q
S
P
D
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
Q349
G
L
Q
H
H
P
H
Q
P
H
P
A
S
N
I
Honey Bee
Apis mellifera
XP_396811
512
55470
A445
A
T
S
M
Q
M
G
A
I
A
P
S
M
G
G
Nematode Worm
Caenorhab. elegans
Q94166
261
30692
C198
G
V
P
E
P
K
D
C
L
K
D
I
S
E
E
Sea Urchin
Strong. purpuratus
XP_781551
476
53123
H414
P
H
A
H
S
H
S
H
G
P
A
G
L
M
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.4
99.3
39.6
N.A.
99.3
99.3
N.A.
76.1
48
N.A.
91.9
N.A.
44.4
41.4
45.7
43.7
Protein Similarity:
100
81.5
99.3
39.6
N.A.
99.3
99.3
N.A.
84.2
62.7
N.A.
95.4
N.A.
53.1
48.2
62.6
49.5
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
40
13.3
N.A.
93.3
N.A.
6.6
13.3
6.6
6.6
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
66.6
46.6
N.A.
100
N.A.
20
40
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
16
8
0
0
0
8
0
16
8
16
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
16
0
8
0
0
0
8
0
0
47
0
% D
% Glu:
0
0
0
62
39
54
0
0
0
0
0
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% F
% Gly:
24
0
0
0
0
0
8
0
8
0
8
8
0
16
8
% G
% His:
0
8
0
24
8
8
8
8
0
16
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
8
8
0
8
% I
% Lys:
0
0
0
0
8
8
8
0
0
8
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
8
8
0
8
8
16
0
0
% L
% Met:
0
0
0
8
0
8
0
0
0
0
0
0
8
8
8
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
16
0
% N
% Pro:
8
8
8
0
8
8
0
0
70
54
16
0
54
0
8
% P
% Gln:
0
0
8
0
8
0
0
8
8
0
54
0
0
0
54
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% R
% Ser:
47
54
62
0
16
8
16
54
0
8
0
54
16
8
0
% S
% Thr:
8
8
0
0
0
0
0
8
0
0
0
8
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _