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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIX1 All Species: 22.12
Human Site: Y246 Identified Species: 40.56
UniProt: Q15475 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15475 NP_005973.1 284 32210 Y246 G H A R S S N Y S L P G L T A
Chimpanzee Pan troglodytes XP_515444 293 32560 S255 L G H P P G P S A V P V P V P
Rhesus Macaque Macaca mulatta XP_001096585 284 32192 Y246 G H T R S S N Y S L P G L T A
Dog Lupus familis XP_547841 714 77250 Y676 G H A R S S N Y S L P G L T A
Cat Felis silvestris
Mouse Mus musculus Q62231 284 32192 Y246 G H A R S S N Y S L P G L T A
Rat Rattus norvegicus NP_446211 284 32192 Y246 G H A R S S N Y S L P G L T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505983 285 31909 L243 S P P G L Q P L H S L G H P Q
Chicken Gallus gallus O42406 314 34658 E277 C P T H S S A E S P S T A A S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_996978 284 31956 Y246 S H P G A S A Y S M T G L G A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27350 416 45006 S374 G G G G G G V S A A A A A Q M
Honey Bee Apis mellifera XP_396811 512 55470 N470 P N T M Q S V N T M N T M S M
Nematode Worm Caenorhab. elegans Q94166 261 30692 H223 S K L S N S F H N P S D L S S
Sea Urchin Strong. purpuratus XP_781551 476 53123 A439 T N L P P G A A E A A A Q A L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.4 99.3 39.6 N.A. 99.3 99.3 N.A. 76.1 48 N.A. 91.9 N.A. 44.4 41.4 45.7 43.7
Protein Similarity: 100 81.5 99.3 39.6 N.A. 99.3 99.3 N.A. 84.2 62.7 N.A. 95.4 N.A. 53.1 48.2 62.6 49.5
P-Site Identity: 100 6.6 93.3 100 N.A. 100 100 N.A. 6.6 20 N.A. 46.6 N.A. 6.6 6.6 13.3 0
P-Site Similarity: 100 20 93.3 100 N.A. 100 100 N.A. 6.6 26.6 N.A. 60 N.A. 13.3 40 46.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 31 0 8 0 24 8 16 16 16 16 16 16 47 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 47 16 8 24 8 24 0 0 0 0 0 54 0 8 0 % G
% His: 0 47 8 8 0 0 0 8 8 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 0 16 0 8 0 0 8 0 39 8 0 54 0 8 % L
% Met: 0 0 0 8 0 0 0 0 0 16 0 0 8 0 16 % M
% Asn: 0 16 0 0 8 0 39 8 8 0 8 0 0 0 0 % N
% Pro: 8 16 16 16 16 0 16 0 0 16 47 0 8 8 8 % P
% Gln: 0 0 0 0 8 8 0 0 0 0 0 0 8 8 8 % Q
% Arg: 0 0 0 39 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 24 0 0 8 47 70 0 16 54 8 16 0 0 16 16 % S
% Thr: 8 0 24 0 0 0 0 0 8 0 8 16 0 39 0 % T
% Val: 0 0 0 0 0 0 16 0 0 8 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 47 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _