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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED22 All Species: 31.82
Human Site: S74 Identified Species: 53.85
UniProt: Q15528 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15528 NP_598395.1 200 22221 S74 N I V R A G E S L M K L V S D
Chimpanzee Pan troglodytes XP_528453 200 22182 S74 N I V R A G E S L M K L V S D
Rhesus Macaque Macaca mulatta XP_001101391 200 22172 S74 N I V R A G E S L M K L V S D
Dog Lupus familis XP_537799 140 16415 L15 P Q S K E T L L Q S Y N K R L
Cat Felis silvestris
Mouse Mus musculus Q62276 200 22263 S74 N I V R A G E S L M K L V S D
Rat Rattus norvegicus A0JPN6 200 22293 S74 N I V R A G E S L M K L V S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510904 140 16290 L15 P Q S K E T L L Q S Y N K R L
Chicken Gallus gallus Q800L3 203 23030 S74 N I V R A G E S L M K L V S D
Frog Xenopus laevis Q6GQ95 201 22927 S74 N I V R A G E S L M K L V S D
Zebra Danio Brachydanio rerio A5WUL3 198 22663 E73 A N I V R A G E S L M K L V S
Tiger Blowfish Takifugu rubipres O57595 200 22905 S74 N I V R A G E S L M K L V S D
Fruit Fly Dros. melanogaster Q9V439 143 16575 L18 P Q S K E A L L K S Y N A R L
Honey Bee Apis mellifera XP_394449 140 16081 L15 P Q S K E A L L K S Y T T R L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_788097 146 16738 Q20 L T Q S K D T Q L K S Y K R R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 99.5 68 N.A. 95 95.5 N.A. 63.5 80.7 74.1 70.5 71 45 49.5 N.A. 46
Protein Similarity: 100 99 99.5 68.5 N.A. 95.5 96 N.A. 67.5 86.6 82.5 79 77.5 57.5 60.5 N.A. 57
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. 0 100 100 0 100 0 0 N.A. 6.6
P-Site Similarity: 100 100 100 6.6 N.A. 100 100 N.A. 6.6 100 100 20 100 6.6 6.6 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 58 22 0 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 58 % D
% Glu: 0 0 0 0 29 0 58 8 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 58 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 58 8 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 29 8 0 0 0 15 8 58 8 22 0 0 % K
% Leu: 8 0 0 0 0 0 29 29 65 8 0 58 8 0 29 % L
% Met: 0 0 0 0 0 0 0 0 0 58 8 0 0 0 0 % M
% Asn: 58 8 0 0 0 0 0 0 0 0 0 22 0 0 0 % N
% Pro: 29 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 29 8 0 0 0 0 8 15 0 0 0 0 0 0 % Q
% Arg: 0 0 0 58 8 0 0 0 0 0 0 0 0 36 8 % R
% Ser: 0 0 29 8 0 0 0 58 8 29 8 0 0 58 8 % S
% Thr: 0 8 0 0 0 15 8 0 0 0 0 8 8 0 0 % T
% Val: 0 0 58 8 0 0 0 0 0 0 0 0 58 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 29 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _