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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSN All Species: 30.61
Human Site: T67 Identified Species: 51.79
UniProt: Q15631 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15631 NP_004613.1 228 26183 T67 K A R E H F G T V K T H L T S
Chimpanzee Pan troglodytes XP_001134810 223 25554 T62 K A R E H F G T V K T H L T S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540996 614 66425 T453 K A R E H F G T V K T H L T S
Cat Felis silvestris
Mouse Mus musculus Q62348 228 26182 T67 K A R E H F S T V K T H L T S
Rat Rattus norvegicus Q9JHB5 290 32987 G96 E S E S K L D G V R Q K M L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521564 241 27394 T80 K A R E H F G T V R T Q L T S
Chicken Gallus gallus P79769 229 25942 T67 K A R E H F G T V R T Q M E S
Frog Xenopus laevis NP_001080426 228 26276 T67 K A R E H Y S T V R D Q L A T
Zebra Danio Brachydanio rerio NP_001020623 227 26149 T67 K A R E L F C T V R N H T G E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610591 235 27007 L68 L A R K Q V E L C A Q K Y Q K
Honey Bee Apis mellifera XP_397233 234 27363 D72 T S R E L F K D V R K N Y I R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781342 241 27362 T69 R S R E L F Q T V R S K I A L
Poplar Tree Populus trichocarpa XP_002326362 239 27283 K75 K A R I G V L K G L Y N R L A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565857 308 35035 K145 K E K I V D L K Q Y Y G R L A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.5 N.A. 36.8 N.A. 98.6 22.7 N.A. 83.8 86 78.9 78.9 N.A. 51 53.4 N.A. 55.1
Protein Similarity: 100 93.4 N.A. 36.9 N.A. 98.6 37.2 N.A. 89.2 92.1 88.5 85.9 N.A. 65.9 73 N.A. 73.8
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 6.6 N.A. 86.6 73.3 53.3 53.3 N.A. 13.3 26.6 N.A. 33.3
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 33.3 N.A. 93.3 86.6 73.3 60 N.A. 20 46.6 N.A. 66.6
Percent
Protein Identity: 37.6 N.A. N.A. 28.9 N.A. N.A.
Protein Similarity: 55.2 N.A. N.A. 44.4 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 72 0 0 0 0 0 0 0 8 0 0 0 15 15 % A
% Cys: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 8 8 0 0 8 0 0 0 0 % D
% Glu: 8 8 8 72 0 0 8 0 0 0 0 0 0 8 8 % E
% Phe: 0 0 0 0 0 65 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 36 8 8 0 0 8 0 8 0 % G
% His: 0 0 0 0 50 0 0 0 0 0 0 36 0 0 0 % H
% Ile: 0 0 0 15 0 0 0 0 0 0 0 0 8 8 0 % I
% Lys: 72 0 8 8 8 0 8 15 0 29 8 22 0 0 8 % K
% Leu: 8 0 0 0 22 8 15 8 0 8 0 0 43 22 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 15 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 15 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 8 0 8 0 8 0 15 22 0 8 8 % Q
% Arg: 8 0 86 0 0 0 0 0 0 50 0 0 15 0 8 % R
% Ser: 0 22 0 8 0 0 15 0 0 0 8 0 0 0 43 % S
% Thr: 8 0 0 0 0 0 0 65 0 0 43 0 8 36 8 % T
% Val: 0 0 0 0 8 15 0 0 79 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 8 15 0 15 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _