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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED1
All Species:
24.24
Human Site:
S227
Identified Species:
48.48
UniProt:
Q15648
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15648
NP_004765.2
1581
168478
S227
M
N
L
K
Y
Y
V
S
P
S
D
L
L
D
D
Chimpanzee
Pan troglodytes
XP_001172395
1581
168474
S227
M
N
L
K
Y
Y
V
S
P
S
D
L
L
D
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537654
1583
168625
S227
M
N
L
K
Y
Y
A
S
P
S
D
L
L
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q925J9
1575
167122
S227
M
N
M
K
Y
Y
A
S
P
S
D
L
L
D
D
Rat
Rattus norvegicus
NP_001127833
1567
166392
D215
K
Y
Y
A
S
P
S
D
L
L
H
D
T
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521297
422
46589
Chicken
Gallus gallus
XP_418125
1594
169410
S239
M
N
L
K
Y
Y
V
S
P
Y
D
L
F
E
D
Frog
Xenopus laevis
Q6INP8
1570
165663
D215
K
Y
Y
V
S
P
Y
D
L
F
D
D
G
T
G
Zebra Danio
Brachydanio rerio
XP_700209
1694
176982
S214
V
S
L
Q
C
Y
V
S
P
N
D
I
F
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VP05
1475
149513
V165
G
D
F
A
D
F
T
V
Q
L
E
G
L
S
S
Honey Bee
Apis mellifera
XP_395879
1811
193227
G232
I
L
E
R
R
R
G
G
H
A
M
K
L
T
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786427
2421
258175
S247
M
R
L
T
Y
F
V
S
P
Y
D
L
L
D
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
98
N.A.
94.4
93.9
N.A.
24.4
87.6
72.5
56.4
N.A.
22
24.4
N.A.
25.7
Protein Similarity:
100
100
N.A.
98.9
N.A.
97.1
96.5
N.A.
25.7
93.5
81.7
69
N.A.
38.9
41.1
N.A.
38.5
P-Site Identity:
100
100
N.A.
93.3
N.A.
86.6
0
N.A.
0
80
6.6
40
N.A.
6.6
6.6
N.A.
66.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
93.3
0
N.A.
0
86.6
6.6
86.6
N.A.
26.6
26.6
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
0
0
17
0
0
9
0
0
0
0
9
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
9
0
0
17
0
0
67
17
0
42
42
% D
% Glu:
0
0
9
0
0
0
0
0
0
0
9
0
0
17
9
% E
% Phe:
0
0
9
0
0
17
0
0
0
9
0
0
17
0
0
% F
% Gly:
9
0
0
0
0
0
9
9
0
0
0
9
9
0
9
% G
% His:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% H
% Ile:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% I
% Lys:
17
0
0
42
0
0
0
0
0
0
0
9
0
0
0
% K
% Leu:
0
9
50
0
0
0
0
0
17
17
0
50
59
0
0
% L
% Met:
50
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
0
42
0
0
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
17
0
0
59
0
0
0
0
0
0
% P
% Gln:
0
0
0
9
0
0
0
0
9
0
0
0
0
0
0
% Q
% Arg:
0
9
0
9
9
9
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
9
0
0
17
0
9
59
0
34
0
0
0
9
9
% S
% Thr:
0
0
0
9
0
0
9
0
0
0
0
0
9
25
0
% T
% Val:
9
0
0
9
0
0
42
9
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
17
17
0
50
50
9
0
0
17
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _