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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TWIST1
All Species:
29.39
Human Site:
S140
Identified Species:
49.74
UniProt:
Q15672
Number Species:
13
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15672
NP_000465.1
202
20954
S140
K
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
Chimpanzee
Pan troglodytes
Q8MI03
201
20743
L139
L
P
K
I
I
P
T
L
P
S
D
K
L
S
K
Rhesus Macaque
Macaca mulatta
XP_001103003
192
19946
D131
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
T
Dog
Lupus familis
XP_862829
199
20704
S137
K
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
P26687
206
21180
S144
K
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
Rat
Rattus norvegicus
P97831
160
18106
D99
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510876
214
24100
S152
K
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
Chicken
Gallus gallus
NP_990070
190
20385
D129
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
T
Frog
Xenopus laevis
P13903
166
18778
D105
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
T
Zebra Danio
Brachydanio rerio
Q7ZSX3
265
30428
Y147
S
H
I
P
T
L
P
Y
E
K
R
L
S
K
V
Tiger Blowfish
Takifugu rubipres
Q90YI8
371
40876
D237
L
I
P
T
H
P
P
D
K
K
L
S
K
N
E
Fruit Fly
Dros. melanogaster
P10627
490
54403
S394
Q
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
Honey Bee
Apis mellifera
NP_001011637
366
42484
S285
K
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001099179
204
23479
S141
K
I
I
P
T
L
P
S
D
K
L
S
K
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
94
98.5
N.A.
95.1
66.3
N.A.
52.3
88.6
70.7
21.8
21.8
23.4
32.5
N.A.
46.5
Protein Similarity:
100
98
94
98.5
N.A.
95.6
72.7
N.A.
62.6
89.1
76.7
34.3
31.8
28.7
39.8
N.A.
55.3
P-Site Identity:
100
0
6.6
100
N.A.
100
6.6
N.A.
100
6.6
6.6
40
40
93.3
100
N.A.
100
P-Site Similarity:
100
6.6
6.6
100
N.A.
100
6.6
N.A.
100
6.6
6.6
46.6
46.6
100
100
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
36
50
0
8
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
29
86
58
8
8
0
0
0
0
0
0
0
29
50
0
% I
% Lys:
43
0
8
0
0
0
0
0
36
65
0
36
58
8
8
% K
% Leu:
15
0
0
0
29
58
0
8
0
29
58
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
8
36
58
0
43
65
0
8
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
0
0
29
50
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
8
0
0
0
0
0
29
50
0
8
29
58
8
8
0
% S
% Thr:
0
0
0
36
58
0
8
0
0
0
0
0
0
0
29
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _