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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN14
All Species:
19.09
Human Site:
S354
Identified Species:
42
UniProt:
Q15678
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15678
NP_005392.2
1187
135261
S354
H
Y
S
E
T
H
T
S
Q
D
S
I
F
H
G
Chimpanzee
Pan troglodytes
XP_001171329
1187
135241
S354
H
Y
S
E
T
H
T
S
Q
D
S
I
F
H
G
Rhesus Macaque
Macaca mulatta
XP_001106167
1187
135194
S354
H
Y
S
E
T
H
T
S
Q
D
S
I
F
H
G
Dog
Lupus familis
XP_849236
1187
134903
S354
H
Y
S
E
T
H
T
S
Q
D
S
I
F
H
G
Cat
Felis silvestris
Mouse
Mus musculus
Q62130
1189
135012
S354
H
Y
S
E
T
H
T
S
Q
D
S
I
F
P
G
Rat
Rattus norvegicus
Q62728
1175
133393
D360
E
P
F
A
S
S
Q
D
N
V
F
V
P
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511302
1193
135259
F359
H
T
S
Q
D
S
I
F
H
G
N
E
E
A
F
Chicken
Gallus gallus
XP_419419
1191
135566
F359
H
N
S
Q
D
S
I
F
H
G
N
E
E
T
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
Y49
L
D
R
S
P
H
E
Y
N
G
R
I
R
N
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
G241
L
P
I
E
I
G
V
G
A
V
G
I
K
V
F
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
E365
G
E
G
A
S
S
E
E
N
L
P
H
H
M
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
95.6
N.A.
91.5
53.7
N.A.
87.9
84.9
N.A.
32.8
N.A.
N.A.
N.A.
24.7
34.5
Protein Similarity:
100
99.7
99.5
97.2
N.A.
95.6
70.7
N.A.
92.1
91.5
N.A.
48.1
N.A.
N.A.
N.A.
42
51.7
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
13.3
13.3
N.A.
20
N.A.
N.A.
N.A.
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
20
N.A.
26.6
26.6
N.A.
26.6
N.A.
N.A.
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
19
0
0
0
0
10
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
19
0
0
10
0
46
0
0
0
0
0
% D
% Glu:
10
10
0
55
0
0
19
10
0
0
0
19
19
0
0
% E
% Phe:
0
0
10
0
0
0
0
19
0
0
10
0
46
0
28
% F
% Gly:
10
0
10
0
0
10
0
10
0
28
10
0
0
0
55
% G
% His:
64
0
0
0
0
55
0
0
19
0
0
10
10
37
0
% H
% Ile:
0
0
10
0
10
0
19
0
0
0
0
64
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% K
% Leu:
19
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% M
% Asn:
0
10
0
0
0
0
0
0
28
0
19
0
0
19
0
% N
% Pro:
0
19
0
0
10
0
0
0
0
0
10
0
10
10
0
% P
% Gln:
0
0
0
19
0
0
10
0
46
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
0
0
0
0
0
0
10
0
10
0
0
% R
% Ser:
0
0
64
10
19
37
0
46
0
0
46
0
0
0
0
% S
% Thr:
0
10
0
0
46
0
46
0
0
0
0
0
0
10
0
% T
% Val:
0
0
0
0
0
0
10
0
0
19
0
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
46
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _