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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MYLK
All Species:
12.73
Human Site:
S280
Identified Species:
40
UniProt:
Q15746
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15746
NP_444253.3
1914
210774
S280
K
E
V
T
N
V
I
S
K
E
S
K
L
D
S
Chimpanzee
Pan troglodytes
XP_001168476
1914
210741
S280
K
E
V
T
S
V
I
S
K
E
S
K
L
D
S
Rhesus Macaque
Macaca mulatta
XP_001113525
1914
210379
S280
R
E
V
T
N
V
I
S
K
E
L
K
L
N
S
Dog
Lupus familis
XP_849008
1914
210137
T277
K
E
V
T
N
G
T
T
Q
G
P
K
L
D
H
Cat
Felis silvestris
Mouse
Mus musculus
Q6PDN3
1941
212907
V270
S
P
D
I
R
K
E
V
T
N
G
V
S
K
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P11799
1906
210428
S275
A
T
K
A
I
E
N
S
D
F
K
Q
A
T
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001099152
899
100637
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787033
2753
301994
K742
H
S
T
I
G
V
M
K
S
P
S
T
G
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.3
87.7
N.A.
84.3
N.A.
N.A.
N.A.
69
N.A.
33.9
N.A.
N.A.
N.A.
N.A.
26.6
Protein Similarity:
100
99.3
98.3
91.9
N.A.
89.4
N.A.
N.A.
N.A.
79.2
N.A.
40.5
N.A.
N.A.
N.A.
N.A.
40.7
P-Site Identity:
100
93.3
80
53.3
N.A.
0
N.A.
N.A.
N.A.
13.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
93.3
66.6
N.A.
0
N.A.
N.A.
N.A.
20
N.A.
0
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
13
0
0
0
0
0
0
0
0
13
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
13
0
0
0
0
0
13
0
0
0
0
38
13
% D
% Glu:
0
50
0
0
0
13
13
0
0
38
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% F
% Gly:
0
0
0
0
13
13
0
0
0
13
13
0
13
0
0
% G
% His:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% H
% Ile:
0
0
0
25
13
0
38
0
0
0
0
0
0
0
0
% I
% Lys:
38
0
13
0
0
13
0
13
38
0
13
50
0
13
13
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
13
0
50
0
0
% L
% Met:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
38
0
13
0
0
13
0
0
0
25
0
% N
% Pro:
0
13
0
0
0
0
0
0
0
13
13
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
13
0
0
13
0
0
0
% Q
% Arg:
13
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
13
13
0
0
13
0
0
50
13
0
38
0
13
0
50
% S
% Thr:
0
13
13
50
0
0
13
13
13
0
0
13
0
13
0
% T
% Val:
0
0
50
0
0
50
0
13
0
0
0
13
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _