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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD2
All Species:
39.7
Human Site:
S458
Identified Species:
72.78
UniProt:
Q15796
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15796
NP_001003652.1
467
52306
S458
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Chimpanzee
Pan troglodytes
XP_001159972
710
77879
S701
K
V
L
T
Q
M
G
S
P
S
I
R
C
S
S
Rhesus Macaque
Macaca mulatta
XP_001111078
455
51358
S446
K
V
L
T
Q
M
G
S
P
S
I
R
C
S
S
Dog
Lupus familis
XP_866258
457
51167
S448
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q62432
467
52248
S458
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Rat
Rattus norvegicus
O70436
467
52221
S458
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505255
467
52247
S458
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Chicken
Gallus gallus
P84023
426
48233
P418
V
L
T
Q
M
G
S
P
S
I
R
C
S
S
V
Frog
Xenopus laevis
NP_001084329
467
52335
S458
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
S459
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
S446
K
V
L
T
Q
M
G
S
P
H
N
A
I
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02330
418
47907
P409
R
V
L
S
T
M
G
P
T
P
R
P
I
S
S
Sea Urchin
Strong. purpuratus
NP_001075435
427
48320
P419
V
L
T
Q
M
V
P
P
D
K
Q
C
S
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53
86.3
92.5
N.A.
99.5
99.3
N.A.
99.1
84.5
98.5
95.3
N.A.
57.5
N.A.
44.3
73.2
Protein Similarity:
100
59.5
92
93.1
N.A.
99.7
99.7
N.A.
100
88.2
99.3
97.6
N.A.
69.5
N.A.
59
81.3
P-Site Identity:
100
93.3
93.3
100
N.A.
100
100
N.A.
100
6.6
100
100
N.A.
73.3
N.A.
40
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
13.3
100
100
N.A.
73.3
N.A.
53.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
16
70
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
85
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
16
0
16
0
0
% I
% Lys:
77
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
16
85
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
16
85
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
24
77
8
0
8
0
0
0
% P
% Gln:
0
0
0
16
77
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
16
70
0
0
0
% R
% Ser:
0
0
0
8
0
0
8
77
8
70
0
0
16
100
85
% S
% Thr:
0
0
16
77
8
0
0
0
8
0
0
0
0
0
0
% T
% Val:
16
85
0
0
0
8
0
0
0
0
54
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _