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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SC4MOL All Species: 18.48
Human Site: S276 Identified Species: 29.05
UniProt: Q15800 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15800 NP_001017369.1 293 35216 S276 D R I F G T D S Q Y N A Y N E
Chimpanzee Pan troglodytes XP_001139385 350 40239 S333 D R I F G T D S Q Y N A Y N E
Rhesus Macaque Macaca mulatta XP_001101334 293 35261 S276 D R I F G T D S Q Y H A Y Y E
Dog Lupus familis XP_532714 293 35180 S276 D R I F G T D S Q F T A Y N E
Cat Felis silvestris
Mouse Mus musculus Q9CRA4 293 34754 A276 D K L F G T D A Q Y H A Y I E
Rat Rattus norvegicus O35532 293 34945 V276 D R I F G T D V Q Y H A Y T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507700 296 35185 A276 D R L F G T D A Q Y L A Y I E
Chicken Gallus gallus Q5ZLL6 296 35467 S276 D R I F G T D S Q F I A Y K E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q7ZW77 291 34789 D273 T W W D R L F D T D S Q F N K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q20027 300 36047 I269 D R L M G Y H I T Y A D L K K
Sea Urchin Strong. purpuratus XP_787442 286 34164 M267 D K I F G T D M Q Y K D Y Y A
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001105744 264 30720 K248 D W L F G T D K D Y R K A K T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39208 281 33124 R264 D W M F G S L R D P L L E E D
Baker's Yeast Sacchar. cerevisiae P53045 309 36461 S284 D Y C L D T E S G P E A K A S
Red Bread Mold Neurospora crassa Q7SBB6 344 40644 R295 D R L G G S Y R E P D G D M F
Conservation
Percent
Protein Identity: 100 64.8 98.6 95.9 N.A. 89 88.7 N.A. 87.1 82 N.A. 78.5 N.A. N.A. N.A. 27.3 57.6
Protein Similarity: 100 69.4 99.3 97.9 N.A. 94.8 93.8 N.A. 92.2 90.8 N.A. 89.4 N.A. N.A. N.A. 42.6 73
P-Site Identity: 100 100 86.6 86.6 N.A. 66.6 80 N.A. 73.3 80 N.A. 6.6 N.A. N.A. N.A. 26.6 60
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 86.6 N.A. 86.6 86.6 N.A. 26.6 N.A. N.A. N.A. 40 66.6
Percent
Protein Identity: N.A. 37.2 N.A. 24.2 36.8 20.3
Protein Similarity: N.A. 54.9 N.A. 41.6 53 37.2
P-Site Identity: N.A. 40 N.A. 20 26.6 20
P-Site Similarity: N.A. 46.6 N.A. 40 33.3 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 14 0 0 7 60 7 7 7 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 94 0 0 7 7 0 67 7 14 7 7 14 7 0 7 % D
% Glu: 0 0 0 0 0 0 7 0 7 0 7 0 7 7 54 % E
% Phe: 0 0 0 74 0 0 7 0 0 14 0 0 7 0 7 % F
% Gly: 0 0 0 7 87 0 0 0 7 0 0 7 0 0 0 % G
% His: 0 0 0 0 0 0 7 0 0 0 20 0 0 0 0 % H
% Ile: 0 0 47 0 0 0 0 7 0 0 7 0 0 14 0 % I
% Lys: 0 14 0 0 0 0 0 7 0 0 7 7 7 20 14 % K
% Leu: 0 0 34 7 0 7 7 0 0 0 14 7 7 0 0 % L
% Met: 0 0 7 7 0 0 0 7 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 14 0 0 27 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 60 0 0 7 0 0 0 % Q
% Arg: 0 60 0 0 7 0 0 14 0 0 7 0 0 0 0 % R
% Ser: 0 0 0 0 0 14 0 40 0 0 7 0 0 0 7 % S
% Thr: 7 0 0 0 0 74 0 0 14 0 7 0 0 7 7 % T
% Val: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % V
% Trp: 0 20 7 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 7 7 0 0 60 0 0 60 14 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _