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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TBCC All Species: 14.85
Human Site: T228 Identified Species: 25.13
UniProt: Q15814 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15814 NP_003183.1 346 39220 T228 N P N T L R L T K A H S C K L
Chimpanzee Pan troglodytes XP_518477 346 39236 T228 N P N T L R L T K A H S C K L
Rhesus Macaque Macaca mulatta XP_001088723 346 39322 T228 N P N T L R L T R T H N C K L
Dog Lupus familis XP_538923 388 42549 A270 N P N T L R L A K A R G C T L
Cat Felis silvestris
Mouse Mus musculus Q8VCN9 341 38106 A223 N P N T L R L A K A R G C K V
Rat Rattus norvegicus NP_001101670 340 38058 A222 N P N T L R L A K A R G C K V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508991 335 37102 A217 N P N T L R L A R A R R C T V
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922489 350 39443 K223 C P S T L H I K N I R S C E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_722959 355 40503 S213 H P G S V Q V S R A S K C T L
Honey Bee Apis mellifera XP_001120828 342 39209 V224 T P S T L H M V N L K Q C T V
Nematode Worm Caenorhab. elegans Q27249 256 29613 D147 K L A M V E A D L E R A E E R
Sea Urchin Strong. purpuratus XP_783718 353 39965 S235 S P S A L H I S N L S D C K I
Poplar Tree Populus trichocarpa XP_002307082 324 36492 N206 C I N A L F V N R L R N C R V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_195702 345 38291 H223 T V N A L F L H R L K K C S V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 95.3 72.9 N.A. 76 74.5 N.A. 61.5 N.A. N.A. 43.7 N.A. 33.5 38.7 21.1 39.6
Protein Similarity: 100 99.1 97.6 78.3 N.A. 84.3 83.5 N.A. 74.5 N.A. N.A. 64 N.A. 57.7 58 40.1 62.6
P-Site Identity: 100 100 80 73.3 N.A. 73.3 73.3 N.A. 60 N.A. N.A. 33.3 N.A. 26.6 26.6 0 26.6
P-Site Similarity: 100 100 93.3 73.3 N.A. 80 80 N.A. 73.3 N.A. N.A. 60 N.A. 73.3 46.6 20 60
Percent
Protein Identity: 29.7 N.A. N.A. 32.3 N.A. N.A.
Protein Similarity: 48.2 N.A. N.A. 51.7 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: 53.3 N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 22 0 0 8 29 0 50 0 8 0 0 0 % A
% Cys: 15 0 0 0 0 0 0 0 0 0 0 0 93 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 8 0 0 8 15 0 % E
% Phe: 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 0 0 0 0 22 0 0 0 % G
% His: 8 0 0 0 0 22 0 8 0 0 22 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 15 0 0 8 0 0 0 0 15 % I
% Lys: 8 0 0 0 0 0 0 8 36 0 15 15 0 43 0 % K
% Leu: 0 8 0 0 86 0 58 0 8 29 0 0 0 0 36 % L
% Met: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 50 0 65 0 0 0 0 8 22 0 0 15 0 0 0 % N
% Pro: 0 79 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 0 0 0 0 50 0 0 36 0 50 8 0 8 8 % R
% Ser: 8 0 22 8 0 0 0 15 0 0 15 22 0 8 0 % S
% Thr: 15 0 0 65 0 0 0 22 0 8 0 0 0 29 0 % T
% Val: 0 8 0 0 15 0 15 8 0 0 0 0 0 0 43 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _