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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STK11 All Species: 19.7
Human Site: S421 Identified Species: 30.95
UniProt: Q15831 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15831 NP_000446.1 433 48636 S421 A R K A C S A S S K I R R L S
Chimpanzee Pan troglodytes XP_524028 433 48572 S421 A R K A C S A S S K I R R L S
Rhesus Macaque Macaca mulatta XP_001093806 433 48511 S421 A R K A C S A S S K I R R L S
Dog Lupus familis XP_542206 439 49298 S427 A R K A C S A S S K I R R L S
Cat Felis silvestris
Mouse Mus musculus Q9WTK7 436 49248 S424 P A R K V C S S N K I R R L S
Rat Rattus norvegicus NP_001101539 436 49227 S424 P A R K V C S S N K I R R L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519859 324 36639 L313 V V P Y L E D L H G Y N V T R
Chicken Gallus gallus Q0GGW5 440 49774 C425 S N P S R K A C S A S S K I R
Frog Xenopus laevis Q91604 432 49054 G420 Q R K A S T T G S K V R K L S
Zebra Danio Brachydanio rerio NP_001017839 440 49807 A428 S R K G L S A A S K I R K L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650302 567 62874 C555 R A K K L T S C I S V R K L S
Honey Bee Apis mellifera XP_623596 434 50409 K417 K Q N S H Q S K R R W R K P I
Nematode Worm Caenorhab. elegans Q9GN62 617 69630 A565 C A P P G P A A G N A Q N S T
Sea Urchin Strong. purpuratus XP_780778 429 48923 I416 E P Q K E K K I S R V R K L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38997 535 61163 E484 E S S I I E N E A A V K S P N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 99.3 92.4 N.A. 90.1 90.5 N.A. 57.7 89.3 81.2 82.2 N.A. 41.4 54.6 29.8 57.7
Protein Similarity: 100 99.3 99.5 94.5 N.A. 93.3 93.1 N.A. 63.2 93.1 87.5 87.2 N.A. 54.8 71.8 43.7 72.2
P-Site Identity: 100 100 100 100 N.A. 46.6 46.6 N.A. 0 13.3 53.3 66.6 N.A. 26.6 6.6 6.6 26.6
P-Site Similarity: 100 100 100 100 N.A. 66.6 66.6 N.A. 0 40 73.3 86.6 N.A. 53.3 40 26.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. 27.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 27 0 34 0 0 47 14 7 14 7 0 0 0 0 % A
% Cys: 7 0 0 0 27 14 0 14 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % D
% Glu: 14 0 0 0 7 14 0 7 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 7 7 0 0 7 7 7 0 0 0 0 0 % G
% His: 0 0 0 0 7 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 7 0 0 7 7 0 47 0 0 7 7 % I
% Lys: 7 0 47 27 0 14 7 7 0 54 0 7 40 0 0 % K
% Leu: 0 0 0 0 20 0 0 7 0 0 0 0 0 67 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 7 0 0 0 7 0 14 7 0 7 7 0 7 % N
% Pro: 14 7 20 7 0 7 0 0 0 0 0 0 0 14 0 % P
% Gln: 7 7 7 0 0 7 0 0 0 0 0 7 0 0 0 % Q
% Arg: 7 40 14 0 7 0 0 0 7 14 0 74 40 0 14 % R
% Ser: 14 7 7 14 7 34 27 40 54 7 7 7 7 7 67 % S
% Thr: 0 0 0 0 0 14 7 0 0 0 0 0 0 7 7 % T
% Val: 7 7 0 0 14 0 0 0 0 0 27 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _