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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD8
All Species:
41.52
Human Site:
Y59
Identified Species:
76.11
UniProt:
Q15843
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15843
NP_006147.1
81
9072
Y59
D
E
K
T
A
A
D
Y
K
I
L
G
G
S
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001098135
81
9132
Y59
D
E
K
T
A
A
D
Y
K
I
L
S
G
S
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P29595
81
8954
Y59
D
E
K
T
A
A
D
Y
K
I
L
G
G
S
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001002557
80
9065
Y59
D
E
K
T
A
A
D
Y
K
I
Q
G
G
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VJ33
84
9327
Y59
D
D
K
T
A
A
D
Y
K
V
Q
G
G
S
V
Honey Bee
Apis mellifera
XP_625200
77
8697
Y59
D
E
K
T
A
Q
D
Y
K
V
Q
G
G
S
V
Nematode Worm
Caenorhab. elegans
Q93725
77
8611
Y59
D
D
K
T
A
A
D
Y
K
V
L
G
G
S
V
Sea Urchin
Strong. purpuratus
P23398
76
8532
Y59
D
G
R
T
L
S
D
Y
N
I
Q
K
E
S
T
Poplar Tree
Populus trichocarpa
XP_002310680
149
16567
Y130
D
D
K
T
A
R
D
Y
N
I
E
G
G
S
V
Maize
Zea mays
NP_001148606
153
17083
Y135
D
D
K
T
A
K
D
Y
N
I
E
G
G
S
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SHE7
80
8872
Y59
D
D
K
T
A
K
D
Y
N
I
E
G
G
S
V
Baker's Yeast
Sacchar. cerevisiae
Q03919
77
8675
A59
D
K
L
T
V
T
D
A
H
L
V
E
G
M
Q
Red Bread Mold
Neurospora crassa
P13117
76
8579
Y59
D
G
R
T
L
S
D
Y
N
I
Q
K
E
S
T
Conservation
Percent
Protein Identity:
100
N.A.
93.8
N.A.
N.A.
98.7
N.A.
N.A.
N.A.
N.A.
N.A.
92.5
N.A.
85.7
90.1
82.7
54.3
Protein Similarity:
100
N.A.
97.5
N.A.
N.A.
98.7
N.A.
N.A.
N.A.
N.A.
N.A.
93.8
N.A.
90.4
92.5
91.3
72.8
P-Site Identity:
100
N.A.
93.3
N.A.
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
93.3
N.A.
80
80
86.6
40
P-Site Similarity:
100
N.A.
93.3
N.A.
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
93.3
N.A.
93.3
86.6
100
53.3
Percent
Protein Identity:
43.6
30
N.A.
80.2
55.5
51.8
Protein Similarity:
46.9
43.7
N.A.
87.6
72.8
72.8
P-Site Identity:
73.3
73.3
N.A.
73.3
26.6
40
P-Site Similarity:
80
80
N.A.
80
46.6
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
77
47
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
100
39
0
0
0
0
100
0
0
0
0
0
0
0
0
% D
% Glu:
0
39
0
0
0
0
0
0
0
0
24
8
16
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
16
0
0
0
0
0
0
0
0
0
70
85
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
70
0
0
0
0
0
% I
% Lys:
0
8
77
0
0
16
0
0
54
0
0
16
0
0
0
% K
% Leu:
0
0
8
0
16
0
0
0
0
8
31
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
39
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
39
0
0
0
8
% Q
% Arg:
0
0
16
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
16
0
0
0
0
0
8
0
93
0
% S
% Thr:
0
0
0
100
0
8
0
0
0
0
0
0
0
0
16
% T
% Val:
0
0
0
0
8
0
0
0
0
24
8
0
0
0
77
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _