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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ETFDH All Species: 37.58
Human Site: S425 Identified Species: 59.05
UniProt: Q16134 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16134 NP_004444.2 617 68495 S425 L T S E N L Q S K T I G L H V
Chimpanzee Pan troglodytes XP_517508 617 68419 S425 L T S E N L Q S K T I G L H V
Rhesus Macaque Macaca mulatta XP_001097120 616 68420 S425 L T S E N L Q S K T I G L H V
Dog Lupus familis XP_853781 600 66768 S408 L T S E N L Q S K T I G L H V
Cat Felis silvestris
Mouse Mus musculus Q921G7 616 68072 S424 L T S E N L Q S K T T G L H V
Rat Rattus norvegicus Q6UPE1 616 68180 S424 L T S E N L Q S K T A G L H V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510390 669 74482 S477 L T T E N L Q S K T L G L H V
Chicken Gallus gallus NP_001026705 477 53116 V297 P G R V E H T V G W P L D R H
Frog Xenopus laevis NP_001087869 616 68418 S424 L T D E N I Q S K T Q G L D V
Zebra Danio Brachydanio rerio NP_001004598 617 68912 S425 I T D E N L Q S Q T T G L Y I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610536 604 65970 A412 F E A I N A D A Q S T A G V E
Honey Bee Apis mellifera XP_624722 606 67014 P414 L I D A E N N P S P T K G L E
Nematode Worm Caenorhab. elegans Q11190 597 65317 E404 E D I Q Q K G E D V Q T I D P
Sea Urchin Strong. purpuratus XP_792035 613 67384 S421 L T Q E D A S S E T A G I N V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08822 631 69615 E422 I K G L P V L E E V E D E D A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.8 92.2 N.A. 92.3 93.1 N.A. 82 65.4 84.2 80.8 N.A. 65.1 67.7 59.9 70
Protein Similarity: 100 99.6 99 94.6 N.A. 95.7 95.9 N.A. 88.4 70.6 91.9 90.5 N.A. 78.9 80.8 75.6 81.8
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 86.6 0 73.3 60 N.A. 6.6 6.6 0 46.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 100 0 80 86.6 N.A. 33.3 6.6 13.3 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 49.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 64.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 0 14 0 7 0 0 14 7 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 20 0 7 0 7 0 7 0 0 7 7 20 0 % D
% Glu: 7 7 0 67 14 0 0 14 14 0 7 0 7 0 14 % E
% Phe: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 7 0 0 0 7 0 7 0 0 67 14 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 47 7 % H
% Ile: 14 7 7 7 0 7 0 0 0 0 27 0 14 0 7 % I
% Lys: 0 7 0 0 0 7 0 0 54 0 0 7 0 0 0 % K
% Leu: 67 0 0 7 0 54 7 0 0 0 7 7 60 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 67 7 7 0 0 0 0 0 0 7 0 % N
% Pro: 7 0 0 0 7 0 0 7 0 7 7 0 0 0 7 % P
% Gln: 0 0 7 7 7 0 60 0 14 0 14 0 0 0 0 % Q
% Arg: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % R
% Ser: 0 0 40 0 0 0 7 67 7 7 0 0 0 0 0 % S
% Thr: 0 67 7 0 0 0 7 0 0 67 27 7 0 0 0 % T
% Val: 0 0 0 7 0 7 0 7 0 14 0 0 0 7 60 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _