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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F4
All Species:
7.58
Human Site:
S223
Identified Species:
15.15
UniProt:
Q16254
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16254
NP_001941.2
413
43960
S223
L
Q
S
P
S
A
V
S
T
P
P
P
L
P
K
Chimpanzee
Pan troglodytes
XP_511025
426
45548
S242
L
Q
S
P
S
A
V
S
T
P
P
P
L
P
K
Rhesus Macaque
Macaca mulatta
XP_001088067
416
44276
P226
P
P
A
V
S
T
P
P
P
L
P
K
P
A
L
Dog
Lupus familis
XP_853975
409
43531
T224
Q
S
P
P
A
V
S
T
P
P
P
L
P
K
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8R0K9
410
43815
T224
Q
S
P
P
A
V
S
T
P
P
P
L
P
K
P
Rat
Rattus norvegicus
Q62814
300
33206
M117
Q
Q
S
I
K
N
V
M
E
D
S
I
N
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506812
384
40812
D197
P
Q
P
A
I
P
P
D
Q
E
A
A
I
P
G
Chicken
Gallus gallus
XP_001231948
414
44371
P224
P
P
V
V
L
P
V
P
P
P
E
D
L
I
Q
Frog
Xenopus laevis
NP_001086706
375
40890
N192
P
I
E
V
L
L
V
N
K
D
T
S
S
S
A
Zebra Danio
Brachydanio rerio
NP_998597
393
42365
L203
S
S
S
S
P
V
V
L
P
V
P
P
P
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624285
300
34327
I116
T
Q
W
I
Q
Q
S
I
K
N
I
E
N
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799123
356
39484
R173
R
G
P
D
N
Q
K
R
Y
M
V
H
L
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.3
97.5
93.4
N.A.
92.4
52.2
N.A.
37
71.2
67.8
63.4
N.A.
N.A.
38
N.A.
50.6
Protein Similarity:
100
94.5
98.5
94.4
N.A.
95.1
62.4
N.A.
47.7
78.7
77.9
74.8
N.A.
N.A.
53.7
N.A.
63.4
P-Site Identity:
100
100
13.3
20
N.A.
20
20
N.A.
13.3
20
6.6
26.6
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
20
33.3
N.A.
33.3
26.6
N.A.
20
26.6
13.3
26.6
N.A.
N.A.
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
17
17
0
0
0
0
9
9
0
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
0
0
9
0
17
0
9
0
17
9
% D
% Glu:
0
0
9
0
0
0
0
0
9
9
9
9
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
9
0
17
9
0
0
9
0
0
9
9
9
9
0
% I
% Lys:
0
0
0
0
9
0
9
0
17
0
0
9
0
25
17
% K
% Leu:
17
0
0
0
17
9
0
9
0
9
0
17
34
0
17
% L
% Met:
0
0
0
0
0
0
0
9
0
9
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
9
0
9
0
9
0
0
17
9
0
% N
% Pro:
34
17
34
34
9
17
17
17
42
42
50
25
34
25
17
% P
% Gln:
25
42
0
0
9
17
0
0
9
0
0
0
0
0
9
% Q
% Arg:
9
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% R
% Ser:
9
25
34
9
25
0
25
17
0
0
9
9
9
9
9
% S
% Thr:
9
0
0
0
0
9
0
17
17
0
9
0
0
0
0
% T
% Val:
0
0
9
25
0
25
50
0
0
9
9
0
0
0
0
% V
% Trp:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _