Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: E2F4 All Species: 5.76
Human Site: T293 Identified Species: 11.52
UniProt: Q16254 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16254 NP_001941.2 413 43960 T293 S L P L G P T T L D T R P L Q
Chimpanzee Pan troglodytes XP_511025 426 45548 T312 S L P L G P T T L D T W P L Q
Rhesus Macaque Macaca mulatta XP_001088067 416 44276 L296 L P L G P T A L D T R P L Q S
Dog Lupus familis XP_853975 409 43531 A294 S L P P G L A A L D T R P L Q
Cat Felis silvestris
Mouse Mus musculus Q8R0K9 410 43815 A294 S L P L G L T A L D T R P L Q
Rat Rattus norvegicus Q62814 300 33206 E187 H V L L I N K E S N S S K P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506812 384 40812 P267 H P S T S F E P I K P D P T E
Chicken Gallus gallus XP_001231948 414 44371 S294 V E S K S S S S D L D P L S N
Frog Xenopus laevis NP_001086706 375 40890 M262 P T G Q T F S M E N T T S S R
Zebra Danio Brachydanio rerio NP_998597 393 42365 A273 N S G P P A V A D T D I S S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624285 300 34327 T186 Y E M F L K S T S G E I K V Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_799123 356 39484 Q243 A P S V V V Q Q Q Q Q Q V R Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.3 97.5 93.4 N.A. 92.4 52.2 N.A. 37 71.2 67.8 63.4 N.A. N.A. 38 N.A. 50.6
Protein Similarity: 100 94.5 98.5 94.4 N.A. 95.1 62.4 N.A. 47.7 78.7 77.9 74.8 N.A. N.A. 53.7 N.A. 63.4
P-Site Identity: 100 93.3 0 73.3 N.A. 86.6 6.6 N.A. 6.6 0 6.6 0 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 93.3 0 73.3 N.A. 86.6 26.6 N.A. 20 13.3 26.6 6.6 N.A. N.A. 20 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 0 9 17 25 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 25 34 17 9 0 0 0 % D
% Glu: 0 17 0 0 0 0 9 9 9 0 9 0 0 0 9 % E
% Phe: 0 0 0 9 0 17 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 17 9 34 0 0 0 0 9 0 0 0 0 0 % G
% His: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 9 0 0 0 9 0 0 17 0 0 0 % I
% Lys: 0 0 0 9 0 9 9 0 0 9 0 0 17 0 0 % K
% Leu: 9 34 17 34 9 17 0 9 34 9 0 0 17 34 0 % L
% Met: 0 0 9 0 0 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 0 9 0 0 0 17 0 0 0 0 9 % N
% Pro: 9 25 34 17 17 17 0 9 0 0 9 17 42 9 0 % P
% Gln: 0 0 0 9 0 0 9 9 9 9 9 9 0 9 42 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 9 25 0 9 9 % R
% Ser: 34 9 25 0 17 9 25 9 17 0 9 9 17 25 9 % S
% Thr: 0 9 0 9 9 9 25 25 0 17 42 9 0 9 9 % T
% Val: 9 9 0 9 9 9 9 0 0 0 0 0 9 9 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _