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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F4
All Species:
13.94
Human Site:
Y394
Identified Species:
27.88
UniProt:
Q16254
Number Species:
11
Phosphosite Substitution
Charge Score:
0.55
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16254
NP_001941.2
413
43960
Y394
P
G
D
H
D
Y
I
Y
N
L
D
E
S
E
G
Chimpanzee
Pan troglodytes
XP_511025
426
45548
E413
I
Y
T
L
D
E
S
E
G
V
C
D
L
F
D
Rhesus Macaque
Macaca mulatta
XP_001088067
416
44276
Y397
P
G
D
H
D
Y
I
Y
N
L
D
E
S
E
G
Dog
Lupus familis
XP_853975
409
43531
S395
Y
I
Y
N
L
D
E
S
E
G
V
C
D
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8R0K9
410
43815
E395
D
Y
I
Y
N
L
D
E
S
E
G
V
C
D
L
Rat
Rattus norvegicus
Q62814
300
33206
G288
F
N
L
D
D
N
E
G
V
C
D
L
F
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506812
384
40812
D368
E
E
Q
I
G
D
T
D
G
S
L
P
A
P
F
Chicken
Gallus gallus
XP_001231948
414
44371
Y395
P
G
D
H
D
Y
I
Y
N
L
D
E
S
E
G
Frog
Xenopus laevis
NP_001086706
375
40890
E363
V
Y
N
L
D
E
S
E
G
V
C
D
L
F
D
Zebra Danio
Brachydanio rerio
NP_998597
393
42365
Y374
P
G
D
H
D
Y
I
Y
N
L
D
E
T
E
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624285
300
34327
E287
D
Y
H
F
N
L
S
E
N
E
G
I
C
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799123
356
39484
E344
Y
F
N
L
D
D
S
E
G
A
A
D
L
F
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.3
97.5
93.4
N.A.
92.4
52.2
N.A.
37
71.2
67.8
63.4
N.A.
N.A.
38
N.A.
50.6
Protein Similarity:
100
94.5
98.5
94.4
N.A.
95.1
62.4
N.A.
47.7
78.7
77.9
74.8
N.A.
N.A.
53.7
N.A.
63.4
P-Site Identity:
100
6.6
100
0
N.A.
0
13.3
N.A.
0
100
6.6
93.3
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
20
100
6.6
N.A.
26.6
20
N.A.
6.6
100
26.6
100
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
9
9
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
17
9
17
0
0
% C
% Asp:
17
0
34
9
67
25
9
9
0
0
42
25
9
25
25
% D
% Glu:
9
9
0
0
0
17
17
42
9
17
0
34
0
34
0
% E
% Phe:
9
9
0
9
0
0
0
0
0
0
0
0
9
25
17
% F
% Gly:
0
34
0
0
9
0
0
9
34
9
17
0
0
0
34
% G
% His:
0
0
9
34
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
9
9
9
0
0
34
0
0
0
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
25
9
17
0
0
0
34
9
9
25
9
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
17
9
17
9
0
0
42
0
0
0
0
0
0
% N
% Pro:
34
0
0
0
0
0
0
0
0
0
0
9
0
9
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
34
9
9
9
0
0
25
0
0
% S
% Thr:
0
0
9
0
0
0
9
0
0
0
0
0
9
0
0
% T
% Val:
9
0
0
0
0
0
0
0
9
17
9
9
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
17
34
9
9
0
34
0
34
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _