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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EXT1 All Species: 27.58
Human Site: S141 Identified Species: 50.56
UniProt: Q16394 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16394 NP_000118.2 746 86255 S141 I L A A I E G S R F Y T S D P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001108202 675 74245 V97 C R G D G L K V F V Y P A S G
Dog Lupus familis XP_539145 746 86191 S141 I L A A I E G S R F Y T S D P
Cat Felis silvestris
Mouse Mus musculus P97464 746 86289 S141 I L A A I E G S R F Y T S D P
Rat Rattus norvegicus NP_001101455 670 74649 K92 D T S K C R G K V L K I F V H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509292 443 50957
Chicken Gallus gallus XP_418396 865 98072 S260 V L A A I E G S R F Y T S D P
Frog Xenopus laevis NP_001083782 738 84810 S133 I L A A I E T S R F Y T S D P
Zebra Danio Brachydanio rerio Q5IGR7 741 85103 S136 I L S T I E G S R F Y T S D P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V730 760 87290 S137 I L T A I Q E S R Y Y T S D P
Honey Bee Apis mellifera XP_391845 711 82974 A130 R A C I F V L A L D T L D R D
Nematode Worm Caenorhab. elegans O01704 378 44434
Sea Urchin Strong. purpuratus XP_783281 693 79753 S115 T L D R D K L S S T Y V K N I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 43.9 99.1 N.A. 99.3 42.3 N.A. 58 78.2 88.4 83.6 N.A. 54.4 55.6 26.2 52.1
Protein Similarity: 100 N.A. 60.4 99.5 N.A. 99.7 58.7 N.A. 58.9 81 94.2 91.9 N.A. 69.8 70.2 37.4 68.2
P-Site Identity: 100 N.A. 6.6 100 N.A. 100 6.6 N.A. 0 93.3 93.3 86.6 N.A. 73.3 0 0 20
P-Site Similarity: 100 N.A. 13.3 100 N.A. 100 13.3 N.A. 0 100 93.3 93.3 N.A. 86.6 6.6 0 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 39 47 0 0 0 8 0 0 0 0 8 0 0 % A
% Cys: 8 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 8 8 0 0 0 0 8 0 0 8 54 8 % D
% Glu: 0 0 0 0 0 47 8 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 8 47 0 0 8 0 0 % F
% Gly: 0 0 8 0 8 0 47 0 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 47 0 0 8 54 0 0 0 0 0 0 8 0 0 8 % I
% Lys: 0 0 0 8 0 8 8 8 0 0 8 0 8 0 0 % K
% Leu: 0 62 0 0 0 8 16 0 8 8 0 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 54 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 8 0 8 0 8 0 0 54 0 0 0 0 8 0 % R
% Ser: 0 0 16 0 0 0 0 62 8 0 0 0 54 8 0 % S
% Thr: 8 8 8 8 0 0 8 0 0 8 8 54 0 0 0 % T
% Val: 8 0 0 0 0 8 0 8 8 8 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 70 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _