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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPE65
All Species:
27.88
Human Site:
S223
Identified Species:
76.67
UniProt:
Q16518
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16518
NP_000320.1
533
60948
S223
K
E
D
P
I
S
K
S
E
I
V
V
Q
F
P
Chimpanzee
Pan troglodytes
XP_001165086
550
62744
S223
E
F
T
N
L
S
S
S
E
N
K
C
L
Y
S
Rhesus Macaque
Macaca mulatta
XP_001095946
533
60943
S223
K
E
D
P
I
S
K
S
E
I
V
V
Q
F
P
Dog
Lupus familis
XP_536572
575
65389
A264
L
G
E
T
V
H
G
A
Q
V
I
C
S
I
A
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZQ5
533
61048
S223
K
E
D
P
I
N
K
S
E
V
V
V
Q
F
P
Rat
Rattus norvegicus
O70276
533
60971
S223
K
E
D
P
I
N
K
S
E
V
V
V
Q
F
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q9YGX2
533
60912
S223
K
E
D
P
M
N
K
S
E
V
V
V
Q
F
P
Frog
Xenopus laevis
NP_001080269
533
60847
S223
K
E
D
P
V
T
K
S
K
V
V
V
Q
F
P
Zebra Danio
Brachydanio rerio
NP_001107125
532
60861
S223
K
S
D
Q
F
E
K
S
K
I
L
V
Q
F
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.3
99.8
39.4
N.A.
93.8
94.3
N.A.
N.A.
90
81.4
75.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
93.6
100
56
N.A.
98.1
98.3
N.A.
N.A.
95.5
92.6
88.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
20
100
0
N.A.
86.6
86.6
N.A.
N.A.
80
73.3
60
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
100
40
N.A.
100
100
N.A.
N.A.
100
100
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
23
0
0
0
% C
% Asp:
0
0
78
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
12
67
12
0
0
12
0
0
67
0
0
0
0
0
0
% E
% Phe:
0
12
0
0
12
0
0
0
0
0
0
0
0
78
0
% F
% Gly:
0
12
0
0
0
0
12
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
45
0
0
0
0
34
12
0
0
12
0
% I
% Lys:
78
0
0
0
0
0
78
0
23
0
12
0
0
0
0
% K
% Leu:
12
0
0
0
12
0
0
0
0
0
12
0
12
0
0
% L
% Met:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
12
0
34
0
0
0
12
0
0
0
0
0
% N
% Pro:
0
0
0
67
0
0
0
0
0
0
0
0
0
0
78
% P
% Gln:
0
0
0
12
0
0
0
0
12
0
0
0
78
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
12
0
0
0
34
12
89
0
0
0
0
12
0
12
% S
% Thr:
0
0
12
12
0
12
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
23
0
0
0
0
56
67
78
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _