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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDB1 All Species: 38.48
Human Site: T446 Identified Species: 60.48
UniProt: Q16531 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16531 NP_001914.3 1140 126968 T446 N G E E V E E T E L M G F V D
Chimpanzee Pan troglodytes XP_508472 1140 126946 T446 N G E E V E E T E L M G F V D
Rhesus Macaque Macaca mulatta XP_001082958 1197 132796 T446 N G E E V E E T E L M G F V D
Dog Lupus familis XP_533275 1140 126935 T446 N G E E V E E T E L M G F V D
Cat Felis silvestris
Mouse Mus musculus Q3U1J4 1140 126834 T446 N G E E V E E T E L M G F V D
Rat Rattus norvegicus Q9ESW0 1140 126843 T446 N G E E V E E T E L M G F V D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q805F9 1140 126936 T446 N G E E V E E T E L T G F V D
Frog Xenopus laevis Q6P6Z0 1140 126814 T446 T G E E V E E T D L A G F V D
Zebra Danio Brachydanio rerio NP_956920 897 99217 I237 I I I G Q E S I T Y H N G D K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9XYZ5 1140 126027 T445 S G E E V E E T E I P G F A S
Honey Bee Apis mellifera XP_396048 1138 126198 T445 N G E E V E E T D I P G F V A
Nematode Worm Caenorhab. elegans Q21554 1134 125700 L440 E E L E D V K L L E I N T D L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002300334 1088 121333 M402 E L Q G I K G M W S L R S L T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M0V3 1088 121288 M402 E L Q G I K G M W S L K S S I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7RYR4 1209 134021 V513 I G E T V E E V S D S G F L T
Conservation
Percent
Protein Identity: 100 98.3 93.7 99.9 N.A. 99.6 98.9 N.A. N.A. 97.1 93.4 71.4 N.A. 60.9 68.5 37.9 N.A.
Protein Similarity: 100 98.7 94.6 99.9 N.A. 99.7 99.5 N.A. N.A. 98.5 96.2 75.3 N.A. 76.4 81.9 61.4 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 80 6.6 N.A. 66.6 73.3 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 86.6 6.6 N.A. 80 86.6 20 N.A.
Percent
Protein Identity: 53.7 N.A. N.A. 53.6 N.A. 21.6
Protein Similarity: 70.7 N.A. N.A. 70.9 N.A. 42.1
P-Site Identity: 0 N.A. N.A. 0 N.A. 46.6
P-Site Similarity: 33.3 N.A. N.A. 26.6 N.A. 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 7 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 0 0 0 14 7 0 0 0 14 54 % D
% Glu: 20 7 74 74 0 80 74 0 54 7 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 74 0 0 % F
% Gly: 0 74 0 20 0 0 14 0 0 0 0 74 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 14 7 7 0 14 0 0 7 0 14 7 0 0 0 7 % I
% Lys: 0 0 0 0 0 14 7 0 0 0 0 7 0 0 7 % K
% Leu: 0 14 7 0 0 0 0 7 7 54 14 0 0 14 7 % L
% Met: 0 0 0 0 0 0 0 14 0 0 40 0 0 0 0 % M
% Asn: 54 0 0 0 0 0 0 0 0 0 0 14 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % P
% Gln: 0 0 14 0 7 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % R
% Ser: 7 0 0 0 0 0 7 0 7 14 7 0 14 7 7 % S
% Thr: 7 0 0 7 0 0 0 67 7 0 7 0 7 0 14 % T
% Val: 0 0 0 0 74 7 0 7 0 0 0 0 0 60 0 % V
% Trp: 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _