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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK14
All Species:
22.12
Human Site:
S254
Identified Species:
40.56
UniProt:
Q16539
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16539
NP_001306.1
360
41293
S254
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
Chimpanzee
Pan troglodytes
Q95NE7
360
41475
E254
I
N
R
M
P
S
H
E
A
R
N
Y
I
Q
S
Rhesus Macaque
Macaca mulatta
XP_001112423
329
37756
F239
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P47811
360
41269
S254
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
Rat
Rattus norvegicus
P70618
360
41303
S254
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232616
360
41440
S254
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
Frog
Xenopus laevis
P47812
361
41700
A255
L
Q
K
I
S
S
E
A
A
R
N
Y
I
Q
S
Zebra Danio
Brachydanio rerio
Q9DGE2
361
41614
E255
I
S
R
M
P
S
H
E
A
R
T
Y
I
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61443
365
42080
S257
M
S
R
I
S
S
E
S
A
R
N
Y
I
R
S
Honey Bee
Apis mellifera
XP_395384
360
41360
S250
M
Q
K
I
L
S
E
S
A
R
N
Y
I
Q
S
Nematode Worm
Caenorhab. elegans
Q17446
377
43900
E265
L
K
K
I
S
S
E
E
A
R
N
Y
I
R
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32485
435
48840
N248
I
N
T
I
C
S
E
N
T
L
K
F
V
T
S
Red Bread Mold
Neurospora crassa
Q96TL5
358
41225
N245
I
N
T
I
A
S
E
N
T
L
R
F
V
K
S
Conservation
Percent
Protein Identity:
100
96.1
89.4
N.A.
N.A.
99.4
98.6
N.A.
N.A.
96.3
88.3
85.8
N.A.
68.4
75
62.8
N.A.
Protein Similarity:
100
97.7
90.8
N.A.
N.A.
99.4
99.1
N.A.
N.A.
98.6
94.7
92.2
N.A.
80.2
85
76.6
N.A.
P-Site Identity:
100
53.3
13.3
N.A.
N.A.
100
100
N.A.
N.A.
100
86.6
40
N.A.
73.3
80
80
N.A.
P-Site Similarity:
100
73.3
33.3
N.A.
N.A.
100
100
N.A.
N.A.
100
100
60
N.A.
93.3
93.3
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.9
50.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
57.9
69.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
85
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
77
24
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
24
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% H
% Ile:
31
0
0
77
0
0
0
0
0
0
0
0
85
0
0
% I
% Lys:
0
39
54
0
8
0
0
0
0
0
8
0
0
8
0
% K
% Leu:
47
0
0
0
8
0
0
0
0
16
0
0
0
0
0
% L
% Met:
16
0
8
16
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
24
0
0
0
0
8
16
0
8
70
0
0
0
8
% N
% Pro:
0
0
0
8
16
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
24
0
0
0
0
0
0
0
0
0
0
0
54
0
% Q
% Arg:
0
0
24
0
0
0
0
0
0
77
8
0
0
16
0
% R
% Ser:
0
16
0
0
54
93
0
47
0
0
0
0
0
8
85
% S
% Thr:
8
0
16
0
0
0
0
0
16
0
8
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
8
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
77
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _