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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK7
All Species:
13.94
Human Site:
S765
Identified Species:
25.56
UniProt:
Q16549
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16549
NP_004707.2
785
86247
S765
W
S
L
S
Q
N
K
S
A
L
D
C
P
H
Q
Chimpanzee
Pan troglodytes
XP_508776
785
86375
S765
W
S
L
S
Q
N
K
S
A
L
D
C
P
H
Q
Rhesus Macaque
Macaca mulatta
XP_001093007
786
86480
S765
W
S
L
S
Q
N
N
S
T
L
D
C
P
H
Q
Dog
Lupus familis
XP_850224
787
86625
S765
W
G
P
S
Q
D
R
S
T
L
N
C
P
H
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61139
770
84397
Q763
H
Q
P
P
D
L
L
Q
G
K
S
G
Q
I
C
Rat
Rattus norvegicus
Q62849
783
85580
K764
W
S
L
S
Q
N
S
K
S
D
L
D
C
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001025528
629
69561
A622
Y
G
S
S
W
S
P
A
E
M
K
E
R
Q
R
Frog
Xenopus laevis
P29119
783
86425
G732
L
R
S
G
G
V
L
G
R
K
R
L
Y
M
L
Zebra Danio
Brachydanio rerio
NP_001076494
709
77055
L702
T
H
S
Q
D
K
V
L
L
I
A
D
T
H
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26016
1269
138609
Q1082
P
S
V
P
P
P
S
Q
T
M
A
T
L
S
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
S883
L
M
F
W
I
V
V
S
L
I
A
A
C
G
I
Sea Urchin
Strong. purpuratus
XP_789974
1055
115221
S946
P
S
M
F
T
C
D
S
T
D
S
A
P
H
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
V772
A
E
H
T
I
D
S
V
L
T
N
E
N
P
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.2
91.1
N.A.
85.3
87.3
N.A.
N.A.
63
37.3
59.6
N.A.
25.6
N.A.
29.1
36
Protein Similarity:
100
99.2
98.7
94.9
N.A.
89.5
91.7
N.A.
N.A.
69.5
52.8
70.9
N.A.
37.8
N.A.
43.7
48.5
P-Site Identity:
100
100
86.6
53.3
N.A.
0
40
N.A.
N.A.
6.6
0
6.6
N.A.
6.6
N.A.
6.6
26.6
P-Site Similarity:
100
100
86.6
73.3
N.A.
0
46.6
N.A.
N.A.
40
0
13.3
N.A.
20
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
48.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
8
16
0
24
16
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
31
16
0
8
% C
% Asp:
0
0
0
0
16
16
8
0
0
16
24
16
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
8
0
0
16
0
0
0
% E
% Phe:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
16
0
8
8
0
0
8
8
0
0
8
0
8
0
% G
% His:
8
8
8
0
0
0
0
0
0
0
0
0
0
47
16
% H
% Ile:
0
0
0
0
16
0
0
0
0
16
0
0
0
8
16
% I
% Lys:
0
0
0
0
0
8
16
8
0
16
8
0
0
0
0
% K
% Leu:
16
0
31
0
0
8
16
8
24
31
8
8
8
0
8
% L
% Met:
0
8
8
0
0
0
0
0
0
16
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
31
8
0
0
0
16
0
8
0
0
% N
% Pro:
16
0
16
16
8
8
8
0
0
0
0
0
39
16
8
% P
% Gln:
0
8
0
8
39
0
0
16
0
0
0
0
8
8
24
% Q
% Arg:
0
8
0
0
0
0
8
0
8
0
8
0
8
0
8
% R
% Ser:
0
47
24
47
0
8
24
47
8
0
16
0
0
8
0
% S
% Thr:
8
0
0
8
8
0
0
0
31
8
0
8
8
0
8
% T
% Val:
0
0
8
0
0
16
16
8
0
0
0
0
0
0
0
% V
% Trp:
39
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _