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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FXN All Species: 22.42
Human Site: T83 Identified Species: 37.95
UniProt: Q16595 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16595 NP_000135.2 210 23135 T83 M N L R K S G T L G H P G S L
Chimpanzee Pan troglodytes XP_001137864 210 23069 T83 M N L R K S G T L G H P G L L
Rhesus Macaque Macaca mulatta XP_001093449 210 23092 T83 M N L R K S G T L G H P G S L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O35943 207 22905 T80 V H L R N L G T L D N P S S L
Rat Rattus norvegicus XP_001078791 208 23008 T81 V H L R N S G T L G N P S S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505861 288 30735 T161 I H L R K A G T L S D K S S L
Chicken Gallus gallus XP_424827 144 16168 N18 L R S T G T L N D K S S L D E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001076485 169 18984 L42 D L H L S G P L G E E K A H H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W385 190 20903 T64 L F S S Q I E T E S T L D G A
Honey Bee Apis mellifera XP_625012 206 23630 S79 N K N L F I I S S N N L S T Q
Nematode Worm Caenorhab. elegans Q9TY03 136 15700 F10 S T I L R N N F V R R S F S S
Sea Urchin Strong. purpuratus XP_001204076 163 18316 R37 T R I S S H H R A L T A D R L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ZR07 187 21412 S61 H D S L T T R S F S S Q G P A
Baker's Yeast Sacchar. cerevisiae Q07540 174 19472 Q48 N H T V N T F Q K R F V E S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.7 92.3 N.A. N.A. 71.9 72.8 N.A. 52.4 55.2 N.A. 45.2 N.A. 37.1 31.4 32.3 39
Protein Similarity: 100 95.7 93.8 N.A. N.A. 77.1 79.5 N.A. 58.6 61.4 N.A. 57.6 N.A. 55.7 50.4 42.3 52.3
P-Site Identity: 100 93.3 100 N.A. N.A. 53.3 66.6 N.A. 53.3 0 N.A. 0 N.A. 6.6 0 6.6 6.6
P-Site Similarity: 100 93.3 100 N.A. N.A. 73.3 86.6 N.A. 73.3 13.3 N.A. 0 N.A. 20 20 33.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 29.5 30.4 N.A.
Protein Similarity: N.A. N.A. N.A. 46.6 43.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 0 8 0 0 8 8 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 0 0 0 0 0 0 8 8 8 0 15 8 0 % D
% Glu: 0 0 0 0 0 0 8 0 8 8 8 0 8 0 8 % E
% Phe: 0 8 0 0 8 0 8 8 8 0 8 0 8 0 0 % F
% Gly: 0 0 0 0 8 8 43 0 8 29 0 0 29 8 0 % G
% His: 8 29 8 0 0 8 8 0 0 0 22 0 0 8 8 % H
% Ile: 8 0 15 0 0 15 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 0 0 29 0 0 0 8 8 0 15 0 0 0 % K
% Leu: 15 8 43 29 0 8 8 8 43 8 0 15 8 8 50 % L
% Met: 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 15 22 8 0 22 8 8 8 0 8 22 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 8 0 0 0 0 36 0 8 0 % P
% Gln: 0 0 0 0 8 0 0 8 0 0 0 8 0 0 8 % Q
% Arg: 0 15 0 43 8 0 8 8 0 15 8 0 0 8 0 % R
% Ser: 8 0 22 15 15 29 0 15 8 22 15 15 29 50 15 % S
% Thr: 8 8 8 8 8 22 0 50 0 0 15 0 0 8 0 % T
% Val: 15 0 0 8 0 0 0 0 8 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _