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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STX1A All Species: 26.06
Human Site: S95 Identified Species: 44.1
UniProt: Q16623 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16623 NP_004594.1 288 33023 S95 K V R S K L K S I E Q S I E Q
Chimpanzee Pan troglodytes XP_001146754 288 33051 S95 D I R R Q Q Q S I E Q S I E Q
Rhesus Macaque Macaca mulatta NP_001028037 288 32987 S95 K V R S K L K S I E Q P I E Q
Dog Lupus familis XP_849756 293 33456 S100 K V R S K L K S I E Q S I E Q
Cat Felis silvestris
Mouse Mus musculus O35526 288 33036 S95 K V R S K L K S I E Q S I E Q
Rat Rattus norvegicus P32851 288 33049 S95 K V R S K L K S I E Q S I E Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001233551 316 35842 S123 K V R S K L K S I E Q S I E Q
Frog Xenopus laevis NP_001086322 286 32704 L93 A N N V R S R L K A M E Q S I
Zebra Danio Brachydanio rerio NP_571598 288 33347 A94 K V R S K L K A I E Q S I E Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24547 291 33630 G98 R V R G K L K G I E Q N I E Q
Honey Bee Apis mellifera XP_393760 291 33455 V99 K V R A K L K V I E Q N I E Q
Nematode Worm Caenorhab. elegans O16000 291 33234 K96 N K V R G K L K L I E N A I D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SRV7 306 34701 E106 K I E E L D R E N L E N R T K
Baker's Yeast Sacchar. cerevisiae P39926 295 33715 L94 Y I S Q A T D L Q Y Q L K A D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93 98.9 93.1 N.A. 98.2 98.6 N.A. N.A. 85.7 67.3 82.9 N.A. 70 69.4 63.2 N.A.
Protein Similarity: 100 95.4 98.9 94.5 N.A. 98.9 99.3 N.A. N.A. 89.8 85.7 93.4 N.A. 83.1 81.4 80 N.A.
P-Site Identity: 100 60 93.3 100 N.A. 100 100 N.A. N.A. 100 0 93.3 N.A. 73.3 80 0 N.A.
P-Site Similarity: 100 80 93.3 100 N.A. 100 100 N.A. N.A. 100 13.3 100 N.A. 86.6 93.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.2 24.4 N.A.
Protein Similarity: N.A. N.A. N.A. 51.3 47.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 8 0 0 8 0 8 0 0 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 8 8 0 0 0 0 0 0 0 15 % D
% Glu: 0 0 8 8 0 0 0 8 0 72 15 8 0 72 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 8 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 22 0 0 0 0 0 0 72 8 0 0 72 8 8 % I
% Lys: 65 8 0 0 65 8 65 8 8 0 0 0 8 0 8 % K
% Leu: 0 0 0 0 8 65 8 15 8 8 0 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 8 8 8 0 0 0 0 0 8 0 0 29 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % P
% Gln: 0 0 0 8 8 8 8 0 8 0 79 0 8 0 72 % Q
% Arg: 8 0 72 15 8 0 15 0 0 0 0 0 8 0 0 % R
% Ser: 0 0 8 50 0 8 0 50 0 0 0 50 0 8 0 % S
% Thr: 0 0 0 0 0 8 0 0 0 0 0 0 0 8 0 % T
% Val: 0 65 8 8 0 0 0 8 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _