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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STX1A All Species: 42.42
Human Site: T161 Identified Species: 71.79
UniProt: Q16623 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16623 NP_004594.1 288 33023 T161 E I T G R T T T S E E L E D M
Chimpanzee Pan troglodytes XP_001146754 288 33051 T161 E I T G R T T T S E E L E D M
Rhesus Macaque Macaca mulatta NP_001028037 288 32987 T161 E I T G R T T T S E E L E D M
Dog Lupus familis XP_849756 293 33456 T166 E I T G R T T T S E E L E D M
Cat Felis silvestris
Mouse Mus musculus O35526 288 33036 T161 E I T G R T T T S E E L E D M
Rat Rattus norvegicus P32851 288 33049 T161 E I T G R T T T S E E L E D M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001233551 316 35842 T189 E I T G R T T T S E E L E D M
Frog Xenopus laevis NP_001086322 286 32704 T159 E I T G K S T T D E E L E E M
Zebra Danio Brachydanio rerio NP_571598 288 33347 T160 E I T G R T T T N E E L E D M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24547 291 33630 N164 E I T G R P T N D D E L E K M
Honey Bee Apis mellifera XP_393760 291 33455 T165 E I T G R T T T N E E L E E M
Nematode Worm Caenorhab. elegans O16000 291 33234 G162 D I A G K Q V G D E D L E E M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SRV7 306 34701 D172 T V T G Q R A D E E A I D R L
Baker's Yeast Sacchar. cerevisiae P39926 295 33715 T160 T I I Q P E A T D E E V E A A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93 98.9 93.1 N.A. 98.2 98.6 N.A. N.A. 85.7 67.3 82.9 N.A. 70 69.4 63.2 N.A.
Protein Similarity: 100 95.4 98.9 94.5 N.A. 98.9 99.3 N.A. N.A. 89.8 85.7 93.4 N.A. 83.1 81.4 80 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 73.3 93.3 N.A. 66.6 86.6 40 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 93.3 100 N.A. 73.3 100 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.2 24.4 N.A.
Protein Similarity: N.A. N.A. N.A. 51.3 47.8 N.A.
P-Site Identity: N.A. N.A. N.A. 20 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 15 0 0 0 8 0 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 8 29 8 8 0 8 58 0 % D
% Glu: 79 0 0 0 0 8 0 0 8 93 86 0 93 22 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 93 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 93 8 0 0 0 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 0 0 15 0 0 0 0 0 0 0 0 8 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 86 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 86 % M
% Asn: 0 0 0 0 0 0 0 8 15 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 8 8 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 72 8 0 0 0 0 0 0 0 8 0 % R
% Ser: 0 0 0 0 0 8 0 0 50 0 0 0 0 0 0 % S
% Thr: 15 0 86 0 0 65 79 79 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 0 0 8 0 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _