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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CPSF6 All Species: 27.58
Human Site: S487 Identified Species: 55.15
UniProt: Q16630 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16630 NP_008938.2 551 59210 S487 I E S K S Y G S G S R R E R S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001117360 588 63452 S524 I E S K S Y G S G S R R E R S
Dog Lupus familis XP_531671 611 65331 S547 I E S K S Y G S G S R R E R S
Cat Felis silvestris
Mouse Mus musculus Q6NVF9 551 59134 S487 I E S K S Y G S G S R R E R S
Rat Rattus norvegicus Q5XI29 462 51054 V401 I E A K S Y S V G A S G S S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL34 551 59341 S487 I E S K S Y G S G S R R E R S
Frog Xenopus laevis Q6DDW4 548 59387 S483 I E S K S Y G S G S R R R E R
Zebra Danio Brachydanio rerio Q6NWC6 545 58757 S480 I E S K S Y G S V A G R R E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VSH4 652 71076 R521 I E A K S Y N R R E R S R S R
Honey Bee Apis mellifera XP_624359 752 82027 S657 V E T K S Y G S A R R E R S R
Nematode Worm Caenorhab. elegans NP_501551 489 53643 D425 K N S R I G H D E R C R Q L V
Sea Urchin Strong. purpuratus XP_782654 898 96357 G820 I E T K S Y G G S S G S S S S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 93.7 87.8 N.A. 99.6 44.8 N.A. N.A. 96.7 88.3 84.3 N.A. 42.3 41.3 31.7 33.3
Protein Similarity: 100 N.A. 93.7 88.7 N.A. 99.8 57.1 N.A. N.A. 97.6 93.2 90.1 N.A. 53.2 49.4 45.9 41.5
P-Site Identity: 100 N.A. 100 100 N.A. 100 46.6 N.A. N.A. 100 80 60 N.A. 40 46.6 13.3 53.3
P-Site Similarity: 100 N.A. 100 100 N.A. 100 60 N.A. N.A. 100 80 66.6 N.A. 46.6 60 26.6 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 0 0 0 0 0 9 17 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % D
% Glu: 0 92 0 0 0 0 0 0 9 9 0 9 42 17 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 9 75 9 59 0 17 9 0 0 0 % G
% His: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % H
% Ile: 84 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 0 92 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 9 0 0 0 0 9 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % Q
% Arg: 0 0 0 9 0 0 0 9 9 17 67 67 34 42 34 % R
% Ser: 0 0 67 0 92 0 9 67 9 59 9 17 17 34 59 % S
% Thr: 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 9 0 0 0 0 0 0 9 9 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 92 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _