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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CPSF6 All Species: 26.06
Human Site: Y303 Identified Species: 52.12
UniProt: Q16630 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16630 NP_008938.2 551 59210 Y303 P P P P V P G Y G P P P G P P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001117360 588 63452 Y340 P P P P V P G Y G P P P G P P
Dog Lupus familis XP_531671 611 65331 Y363 P P P P V P G Y G P P P G P P
Cat Felis silvestris
Mouse Mus musculus Q6NVF9 551 59134 Y303 P P P P V P G Y G P P P G P P
Rat Rattus norvegicus Q5XI29 462 51054 F243 P P P L S S S F G V P P P P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL34 551 59341 Y303 P P P P V P G Y G P P P G P P
Frog Xenopus laevis Q6DDW4 548 59387 Y302 P G P P P P G Y G P P P G P P
Zebra Danio Brachydanio rerio Q6NWC6 545 58757 Y300 P G P P P P G Y G P P P G P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VSH4 652 71076 G335 R R P P M H G G F P P Q G P P
Honey Bee Apis mellifera XP_624359 752 82027 G485 G P P P G S M G G P P G G P A
Nematode Worm Caenorhab. elegans NP_501551 489 53643 Q237 R P T P L M S Q P T S L P S N
Sea Urchin Strong. purpuratus XP_782654 898 96357 P509 P P P P M Q G P P P P M Q G P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 93.7 87.8 N.A. 99.6 44.8 N.A. N.A. 96.7 88.3 84.3 N.A. 42.3 41.3 31.7 33.3
Protein Similarity: 100 N.A. 93.7 88.7 N.A. 99.8 57.1 N.A. N.A. 97.6 93.2 90.1 N.A. 53.2 49.4 45.9 41.5
P-Site Identity: 100 N.A. 100 100 N.A. 100 53.3 N.A. N.A. 100 86.6 86.6 N.A. 53.3 53.3 13.3 53.3
P-Site Similarity: 100 N.A. 100 100 N.A. 100 60 N.A. N.A. 100 86.6 86.6 N.A. 60 53.3 20 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 9 9 0 0 0 0 0 0 % F
% Gly: 9 17 0 0 9 0 75 17 75 0 0 9 75 9 0 % G
% His: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 9 9 0 0 0 0 0 0 9 0 0 0 % L
% Met: 0 0 0 0 17 9 9 0 0 0 0 9 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % N
% Pro: 75 75 92 92 17 59 0 9 17 84 92 67 17 84 84 % P
% Gln: 0 0 0 0 0 9 0 9 0 0 0 9 9 0 0 % Q
% Arg: 17 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 9 17 17 0 0 0 9 0 0 9 0 % S
% Thr: 0 0 9 0 0 0 0 0 0 9 0 0 0 0 0 % T
% Val: 0 0 0 0 42 0 0 0 0 9 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 59 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _