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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CPSF6 All Species: 23.33
Human Site: Y395 Identified Species: 46.67
UniProt: Q16630 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16630 NP_008938.2 551 59210 Y395 P P Y D R G D Y G P P G R E M
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001117360 588 63452 Y432 P P Y D R G D Y G P P G R E M
Dog Lupus familis XP_531671 611 65331 Y455 P P Y D R G D Y G P P G R E M
Cat Felis silvestris
Mouse Mus musculus Q6NVF9 551 59134 Y395 P P Y D R G D Y G P P G R E M
Rat Rattus norvegicus Q5XI29 462 51054 N309 M K A S T P Y N H H G S R D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL34 551 59341 Y395 P P Y D R G D Y G P P G R E M
Frog Xenopus laevis Q6DDW4 548 59387 Y391 P P Y E R G D Y G P P G R D M
Zebra Danio Brachydanio rerio Q6NWC6 545 58757 D388 R P P P Y D R D F P G G R D M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VSH4 652 71076 P429 W P P P Q G K P P G P F P D P
Honey Bee Apis mellifera XP_624359 752 82027 G565 P A A Q P P Y G A P G P D H R
Nematode Worm Caenorhab. elegans NP_501551 489 53643 S333 N R P P Q L G S M G V Q P L M
Sea Urchin Strong. purpuratus XP_782654 898 96357 A728 Y T Q Q E Y R A P S E P D R Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 93.7 87.8 N.A. 99.6 44.8 N.A. N.A. 96.7 88.3 84.3 N.A. 42.3 41.3 31.7 33.3
Protein Similarity: 100 N.A. 93.7 88.7 N.A. 99.8 57.1 N.A. N.A. 97.6 93.2 90.1 N.A. 53.2 49.4 45.9 41.5
P-Site Identity: 100 N.A. 100 100 N.A. 100 6.6 N.A. N.A. 100 86.6 33.3 N.A. 20 13.3 6.6 0
P-Site Similarity: 100 N.A. 100 100 N.A. 100 13.3 N.A. N.A. 100 100 40 N.A. 33.3 13.3 13.3 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 17 0 0 0 0 9 9 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 42 0 9 50 9 0 0 0 0 17 34 0 % D
% Glu: 0 0 0 9 9 0 0 0 0 0 9 0 0 42 0 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 9 0 0 0 % F
% Gly: 0 0 0 0 0 59 9 9 50 17 25 59 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 9 9 0 0 0 9 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 9 0 0 0 0 9 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % L
% Met: 9 0 0 0 0 0 0 0 9 0 0 0 0 0 67 % M
% Asn: 9 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % N
% Pro: 59 67 25 25 9 17 0 9 17 67 59 17 17 0 9 % P
% Gln: 0 0 9 17 17 0 0 0 0 0 0 9 0 0 9 % Q
% Arg: 9 9 0 0 50 0 17 0 0 0 0 0 67 9 9 % R
% Ser: 0 0 0 9 0 0 0 9 0 9 0 9 0 0 9 % S
% Thr: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 50 0 9 9 17 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _