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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPKAPK3
All Species:
19.96
Human Site:
S376
Identified Species:
43.9
UniProt:
Q16644
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16644
NP_004626.1
382
42987
S376
Q
A
G
S
S
S
A
S
Q
G
C
N
N
Q
_
Chimpanzee
Pan troglodytes
XP_516486
382
43022
S376
Q
A
G
S
S
S
A
S
Q
G
C
N
N
Q
_
Rhesus Macaque
Macaca mulatta
XP_001097105
382
42997
S376
Q
A
G
S
S
S
A
S
Q
G
C
N
N
Q
_
Dog
Lupus familis
XP_541872
454
51429
A447
Q
A
G
S
G
S
S
A
S
Q
G
C
N
N
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q3UMW7
384
43275
S378
Q
A
G
S
S
S
A
S
Q
G
C
N
N
Q
_
Rat
Rattus norvegicus
Q66H84
384
43204
S378
Q
G
G
S
S
S
A
S
P
G
C
N
N
Q
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520888
313
36136
Chicken
Gallus gallus
Q5F3L1
789
89022
T743
M
K
K
T
S
T
S
T
E
T
R
S
S
S
S
Frog
Xenopus laevis
NP_001085020
377
43533
Zebra Danio
Brachydanio rerio
NP_001073548
408
45999
G401
A
A
T
G
E
K
S
G
G
S
G
C
S
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49071
359
41383
M353
I
E
E
M
E
L
Y
M
A
N
A
T
R
N
_
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.2
79.7
N.A.
94.2
93.2
N.A.
61.2
21.1
67.2
70.8
N.A.
58.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
99.4
81.2
N.A.
96
95.3
N.A.
71.9
30.2
79
80.8
N.A.
71.4
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
40
N.A.
100
85.7
N.A.
0
6.6
0
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
53.3
N.A.
100
85.7
N.A.
0
53.3
0
20
N.A.
0
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
55
0
0
0
0
46
10
10
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
46
19
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
10
0
19
0
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
55
10
10
0
0
10
10
46
19
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
10
0
0
10
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% L
% Met:
10
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
46
55
19
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% P
% Gln:
55
0
0
0
0
0
0
0
37
10
0
0
0
46
19
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% R
% Ser:
0
0
0
55
55
55
28
46
10
10
0
10
19
19
10
% S
% Thr:
0
0
10
10
0
10
0
10
0
10
0
10
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% _