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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTGIS All Species: 24.24
Human Site: S242 Identified Species: 59.26
UniProt: Q16647 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16647 NP_000952.1 500 57104 S242 S R L W K L L S P A R L A R R
Chimpanzee Pan troglodytes XP_514713 657 74033 S399 S R L W K L L S P A R L A T R
Rhesus Macaque Macaca mulatta XP_001098575 500 56976 S242 S R L W K L L S P A R L A T R
Dog Lupus familis XP_543043 543 61103 S285 G R L W K L L S P A R L A T R
Cat Felis silvestris
Mouse Mus musculus O35074 501 57028 S243 N R L W K L L S P A R L A S R
Rat Rattus norvegicus Q62969 501 57109 S243 S R L W K L L S P A G L A S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507523 486 55712 S240 N K S C W V E S Y R E H L E A
Chicken Gallus gallus NP_001005571 510 58909 S250 R F F W D A L S V S K D S Q K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001104630 480 55221 R241 S G L D R K P R E Q S W L G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VMT5 502 57253 F255 A K D V A A F F Y D L M Q K C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.8 97.4 78.4 N.A. 85.8 83.8 N.A. 63.5 46.4 N.A. 47.4 N.A. 20.7 N.A. N.A. N.A.
Protein Similarity: 100 75.1 98.4 85.6 N.A. 92.4 91 N.A. 77 63.3 N.A. 67 N.A. 40.6 N.A. N.A. N.A.
P-Site Identity: 100 93.3 93.3 86.6 N.A. 86.6 86.6 N.A. 6.6 20 N.A. 13.3 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 93.3 93.3 86.6 N.A. 93.3 86.6 N.A. 26.6 53.3 N.A. 20 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 10 20 0 0 0 60 0 0 60 0 10 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 10 10 10 0 0 0 0 10 0 10 0 0 0 % D
% Glu: 0 0 0 0 0 0 10 0 10 0 10 0 0 10 0 % E
% Phe: 0 10 10 0 0 0 10 10 0 0 0 0 0 0 0 % F
% Gly: 10 10 0 0 0 0 0 0 0 0 10 0 0 10 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 20 0 0 60 10 0 0 0 0 10 0 0 10 10 % K
% Leu: 0 0 70 0 0 60 70 0 0 0 10 60 20 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 10 0 60 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 0 0 10 10 0 % Q
% Arg: 10 60 0 0 10 0 0 10 0 10 50 0 0 10 60 % R
% Ser: 50 0 10 0 0 0 0 80 0 10 10 0 10 20 10 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 30 0 % T
% Val: 0 0 0 10 0 10 0 0 10 0 0 0 0 0 0 % V
% Trp: 0 0 0 70 10 0 0 0 0 0 0 10 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 20 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _