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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDK4
All Species:
44.24
Human Site:
Y218
Identified Species:
88.48
UniProt:
Q16654
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16654
NP_002603.1
411
46469
Y218
S
R
M
L
C
D
Q
Y
Y
L
S
S
P
E
L
Chimpanzee
Pan troglodytes
XP_527822
411
46465
Y218
S
R
M
L
C
D
Q
Y
Y
L
T
S
P
E
L
Rhesus Macaque
Macaca mulatta
XP_001093255
411
46497
Y218
S
R
M
L
C
D
Q
Y
Y
L
T
S
P
E
L
Dog
Lupus familis
XP_548195
458
51349
Y265
A
K
L
L
C
D
K
Y
Y
M
A
S
P
D
L
Cat
Felis silvestris
Mouse
Mus musculus
O70571
412
46578
Y218
A
K
M
L
C
D
Q
Y
Y
L
T
S
P
E
L
Rat
Rattus norvegicus
O54937
412
46660
Y218
A
K
M
L
C
D
Q
Y
Y
L
T
S
P
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517852
325
36702
K140
A
Q
G
I
I
E
Y
K
D
A
C
P
V
D
L
Chicken
Gallus gallus
XP_418671
414
46867
Y224
S
K
M
L
C
D
Q
Y
Y
L
T
S
P
E
L
Frog
Xenopus laevis
NP_001083278
404
46003
Y215
A
K
M
L
C
E
Q
Y
Y
L
A
S
P
E
L
Zebra Danio
Brachydanio rerio
XP_001332594
409
46623
Y215
A
R
M
L
C
D
Q
Y
Y
L
N
S
P
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91622
413
46608
Y216
A
R
F
L
C
D
Q
Y
Y
L
T
S
P
A
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02332
401
45263
Y211
A
R
F
L
C
D
R
Y
Y
L
T
S
P
S
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
58.2
N.A.
92.7
92.2
N.A.
70.3
77.7
72
64.7
N.A.
50.6
N.A.
47.6
N.A.
Protein Similarity:
100
100
99.5
74
N.A.
96.8
96.3
N.A.
74.4
88.1
85.4
82.7
N.A.
68.5
N.A.
65.9
N.A.
P-Site Identity:
100
93.3
93.3
53.3
N.A.
80
80
N.A.
6.6
86.6
73.3
80
N.A.
73.3
N.A.
60
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
40
100
100
100
N.A.
86.6
N.A.
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
67
0
0
0
0
0
0
0
0
9
17
0
0
9
0
% A
% Cys:
0
0
0
0
92
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
0
0
0
0
0
84
0
0
9
0
0
0
0
25
0
% D
% Glu:
0
0
0
0
0
17
0
0
0
0
0
0
0
59
0
% E
% Phe:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
42
0
0
0
0
9
9
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
92
0
0
0
0
0
84
0
0
0
0
92
% L
% Met:
0
0
67
0
0
0
0
0
0
9
0
0
0
0
9
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
9
92
0
0
% P
% Gln:
0
9
0
0
0
0
75
0
0
0
0
0
0
0
0
% Q
% Arg:
0
50
0
0
0
0
9
0
0
0
0
0
0
0
0
% R
% Ser:
34
0
0
0
0
0
0
0
0
0
9
92
0
9
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
59
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
92
92
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _