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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK6
All Species:
31.52
Human Site:
Y182
Identified Species:
69.33
UniProt:
Q16659
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16659
NP_002739.1
721
82681
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001083937
721
82621
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Dog
Lupus familis
XP_535486
722
82803
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61532
720
82181
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Rat
Rattus norvegicus
P27704
720
82256
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517230
448
51758
Chicken
Gallus gallus
Q5F3W3
721
82729
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Frog
Xenopus laevis
P26696
361
41238
Zebra Danio
Brachydanio rerio
NP_001039017
729
83177
Y182
A
R
I
M
D
P
H
Y
S
H
K
G
H
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792156
763
86571
Y203
A
R
I
V
D
P
D
Y
S
H
K
G
Y
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q00772
484
55617
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.3
98.4
N.A.
94.7
93.9
N.A.
56.3
92.9
24.8
75.7
N.A.
N.A.
N.A.
N.A.
32.5
Protein Similarity:
100
N.A.
99.7
99.3
N.A.
96.9
96.8
N.A.
58.6
96.5
34.8
85
N.A.
N.A.
N.A.
N.A.
49.9
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
0
100
0
100
N.A.
N.A.
N.A.
N.A.
73.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
0
100
0
100
N.A.
N.A.
N.A.
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
73
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
73
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
73
0
0
0
% G
% His:
0
0
0
0
0
0
64
0
0
73
0
0
64
0
0
% H
% Ile:
0
0
73
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
73
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
73
0
% L
% Met:
0
0
0
64
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
73
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
73
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
73
0
0
0
0
0
64
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
73
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _