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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN21 All Species: 27.88
Human Site: S327 Identified Species: 55.76
UniProt: Q16825 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16825 NP_008970.2 1174 133281 S327 P I R R R S S S R M S L P K P
Chimpanzee Pan troglodytes XP_510107 1174 133325 S327 P V R R R S S S R M S L P K P
Rhesus Macaque Macaca mulatta XP_001083418 1174 133288 S327 P I R R R S S S R M S L P K P
Dog Lupus familis XP_547945 1170 132251 S327 P L R R R S S S R V S L P K P
Cat Felis silvestris
Mouse Mus musculus Q62136 1176 133472 S327 S V R R D S S S R M S L P K P
Rat Rattus norvegicus Q62728 1175 133393 S327 S V R R G S S S R M S L P K P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516721 825 93182 P54 Q P F L Q P S P M S S N P S I
Chicken Gallus gallus XP_421308 1185 135558 S327 P V R R R S S S R M S M P K P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001339962 834 94004 S63 G S V Y S A Q S T S S L N N P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V8R9 1698 184149 Y333 V F G S T Y R Y K G R T Q A E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P28191 1026 115075 N255 F H E G I K M N E Y A W V R I
Sea Urchin Strong. purpuratus XP_796215 1318 147575 K327 V D G F P A D K L I T V V D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97.9 89.4 N.A. 89 88 N.A. 58.6 85.1 N.A. 51.8 N.A. 20.2 N.A. 26.1 34.7
Protein Similarity: 100 99.4 98.7 93.1 N.A. 93 92.5 N.A. 63.3 91.8 N.A. 59.4 N.A. 37 N.A. 42.5 52.5
P-Site Identity: 100 93.3 100 86.6 N.A. 80 80 N.A. 20 86.6 N.A. 26.6 N.A. 0 N.A. 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 86.6 86.6 N.A. 26.6 100 N.A. 33.3 N.A. 6.6 N.A. 20 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 17 0 0 0 0 9 0 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 9 0 9 0 0 0 0 0 0 9 0 % D
% Glu: 0 0 9 0 0 0 0 0 9 0 0 0 0 0 9 % E
% Phe: 9 9 9 9 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 0 17 9 9 0 0 0 0 9 0 0 0 0 0 % G
% His: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 17 0 0 9 0 0 0 0 9 0 0 0 0 17 % I
% Lys: 0 0 0 0 0 9 0 9 9 0 0 0 0 59 0 % K
% Leu: 0 9 0 9 0 0 0 0 9 0 0 59 0 0 0 % L
% Met: 0 0 0 0 0 0 9 0 9 50 0 9 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 9 0 0 0 9 9 9 0 % N
% Pro: 42 9 0 0 9 9 0 9 0 0 0 0 67 0 75 % P
% Gln: 9 0 0 0 9 0 9 0 0 0 0 0 9 0 0 % Q
% Arg: 0 0 59 59 42 0 9 0 59 0 9 0 0 9 0 % R
% Ser: 17 9 0 9 9 59 67 67 0 17 75 0 0 9 0 % S
% Thr: 0 0 0 0 9 0 0 0 9 0 9 9 0 0 0 % T
% Val: 17 34 9 0 0 0 0 0 0 9 0 9 17 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 9 0 9 0 9 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _